About: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

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About: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Creator	Nielsen, J Klingström, Jonas Albert, Jan Price, David Ljunggren, Hans-Gustaf Allander, Tobias Gredmark-Russ, Sara Nielsen, Morten Group, Study Price, J Sandberg, Johan Aleman, Soo Bogdanovic, Gordana Rooyackers, Olav Sönnerborg, Anders Kamal, S Aleman, H.-G Allander, A Björkström, Niklas Björkström, S Bogdanovic, H Buggert, Marcus Covid-19, Karolinska Emgård, Johanna Eriksson, L Eriksson, Lars Folkesson, Elin Folkesson, J Gorin, Jean-Baptiste Henter, Jan-Inge Kamal, Habiba Kammann, D Kammann, Tobias Ljunggren, D Llewellyn-Lacey, Sian Muschiol, Sandra Olsson, Annika Olsson, J.-B Parrot, Tiphaine Perez-Potti, André Rivera-Ballesteros, Olga Rooyackers, O Sekine, T Sekine, Takuya Strålin, Kristoffer Strålin, O Sönnerborg, J.-I Wullimann, David Wullimann, S
Source	Elsevier; PMC
abstract	Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.08.017
has license	els-covid
sha1sum (hex)	4fd8f345ee1db93407c196775bf443c1bb3ba984
schema:url	https://doi.org/10.1016/j.cell.2020.08.017
resource representing a document's title	Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
has PubMed Central identifier	PMC7427556
schema:publication	Cell
resource representing a document's body	covid:4fd8f345ee1db93407c196775bf443c1bb3ba984#body_text
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