About: Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients

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About: Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients
Creator	Shi, Yi Wang, Jian Mao, Panyong Liu, Yang Zhang, Ning Zhang, Jie Bai, Changqing Yang, Penghui Zhang, Shaogeng Zhao, Yingze Bi, Yuhai Wu, Guizhen Wu, X Wang, Z Gao, George Wang, Zhifeng Liu, Chuanyu Wang, Y Wu, Yanan Chen, Zhihai Liu, Peipei Liu, Z Yuan, Yue Xu, Ziqian Gao, Qianqian Chen, S Gao, F Hu, Y Li, Q Liu, G Liu, J Liu, L Liu, William Meng, Fanping Shi, Y Sun, X Wang, Fusheng Wang, G Xu, J Xu, Q Yan, Jin Yang, L Zhang, Y Huang, Z Song, Rui Song, Z Wu, B Xu, X Xu, Xun Zhao, P Deng, Y Huang, Yunting Liu, Longqi Wei, Xiaoyu Yu, Yeya Zhuang, Zhenkun Bi, P Zhu, Linnan Bai, F Deng, Qiuting Diao, Guanghao Diao, J Gao, C Hu, Guohai Lei, Guanglin Lei, N Li, Ziyi Mao, C Meng, G Sun, Hai-Xi Wang, Mingyue Wang, Xiaoqian Xu, Qumiao Ye, Beiwei Ye, H.-X Yu, Linxiang Yuan, M Zhuang, Y
source	Elsevier; Medline; PMC
abstract	SUMMARY COVID-19 is a severe infectious disease that is a current global health threat. However, little is known about its hallmarks compared to other infectious diseases. Here, we report the single-cell transcriptional landscape of longitudinally collected peripheral blood mononuclear cells (PBMCs) in both COVID-19 and influenza A virus (IAV)-infected patients. We observed increase of plasma cells in both COVID-19 and IAV patients, and XAF1-, TNF- and FAS-induced T cell apoptosis in COVID-19 patients. Further analyses revealed distinct signaling pathways activated in COVID-19 (STAT1 and IRF3) vs. IAV (STAT3 and NFκB) patients and substantial differences in the expression of key factors. These factors include relatively increase of IL6R and IL6ST expression in COVID-19 patients, but similarly increased IL-6 concentrations compared to IAV patients, supporting the clinical observations of increased pro-inflammatory cytokines in COVID-19 patients. Thus, we provide the landscape of PBMCs and unveil distinct immune response pathways in COVID-19 and IAV patients.
has issue date	2020-07-19(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2020.07.009
bibo:pmid	32783921
has license	els-covid
sha1sum (hex)	4fac710fbdbf967a7d8ad9a5cef544050d4843ee
schema:url	https://doi.org/10.1016/j.immuni.2020.07.009
resource representing a document's title	Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients
has PubMed Central identifier	PMC7368915
has PubMed identifier	32783921
schema:publication	Immunity
resource representing a document's body	covid:4fac710fbdbf967a7d8ad9a5cef544050d4843ee#body_text
is schema:about of	named entity 'peripheral blood mononuclear cells' named entity 'landscapes' named entity 'Single-cell sequencing' named entity 'influenza'

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