About: The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of Chickens

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About: The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of Chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of Chickens
Creator	Amarasinghe, Aruna Gomis, Susantha Czub, Markus De, Upasama Faizal Abdul-Careem, Mohamed Sarjoon Abdul-Cader, Mohamed Senapathi, Silva Van Marle, Guido
Source	PMC
abstract	The in ovo delivery of cytosine-guanosine (CpG) oligodeoxynucleotides (ODNs) protects chickens against many bacterial and viral infections, by activating the toll-like receptor (TLR)21 signaling pathway. Although the delivery of CpG ODNs in ovo at embryo day (ED) 18 has been shown to reduce infectious bronchitis virus (IBV) loads in embryonic chicken lungs pre-hatch, whether in ovo delivered CpG ODNs are capable of protecting chickens against a post-hatch challenge is unknown. Thus, our objectives were to determine the protective effect of the in ovo delivery of CpG ODNs at ED 18 against IBV infection encountered post-hatch and, then, to investigate the mechanisms of protection. We found significantly higher survival rates and reduced IBV infection in the chickens following the pre-treatment of the ED 18 eggs with CpG ODNs. At 3 days post infection (dpi), we found an increased recruitment of macrophages, cluster of differentiation (CD)8α+ and CD4+ T lymphocytes, and an up-regulation of interferon (IFN)-γ mRNA in the respiratory tract of the chickens. Overall, it may be inferred that CpG ODNs, when delivered in ovo, provide protection against IBV infection induced morbidity and mortality with an enhanced immune response.
has issue date	2018-11-15(xsd:dateTime)
bibo:doi	10.3390/v10110635
bibo:pmid	30445707
has license	cc-by
sha1sum (hex)	4faaf584315206f342db3f18a118eae7ca702146
schema:url	https://doi.org/10.3390/v10110635
resource representing a document's title	The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of Chickens
has PubMed Central identifier	PMC6266937
has PubMed identifier	30445707
schema:publication	Viruses
resource representing a document's body	covid:4faaf584315206f342db3f18a118eae7ca702146#body_text
is schema:about of	named entity 'CHICKENS' named entity 'TO REDUCE' named entity 'DETERMINE' named entity 'OLIGODEOXYNUCLEOTIDES' named entity 'RECRUITMENT' named entity 'DELIVERY' named entity 'CPG' named entity 'CD4' named entity 'OVERALL' named entity 'POST' covid:arg/4faaf584315206f342db3f18a118eae7ca702146 named entity 'CLUSTER OF DIFFERENTIATION' named entity 'INTERFERON ' named entity 'BACTERIAL' named entity 'ACTIVATING' named entity 'CHICKENS' named entity 'INFECTIOUS BRONCHITIS' named entity 'VIRUSES' named entity 'COMMUNICATION' named entity 'CHALLENGE' named entity 'FOUND' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'MACROPHAGES' named entity 'DAY' named entity 'OLIGONUCLEOTIDES' named entity 'IN OVO' named entity 'RESPIRATORY TRACT' named entity 'PROVIDE' named entity 'IMMUNE RESPONSE' named entity 'EMBRYO' named entity 'DELIVERY' named entity 'OUR' named entity 'PROTECTING' named entity 'HATCH' named entity 'CPG' named entity 'INCREASED' named entity 'T LYMPHOCYTES' named entity 'IN OVO' named entity 'RECRUITMENT' named entity 'VIRAL INFECTIONS' named entity 'PRE' named entity 'PROTECTIVE EFFECT' named entity 'OBJECTIVES' named entity 'UNKNOWN' named entity 'SIGNALING PATHWAY' named entity 'UP-REGULATION' named entity 'REDUCED' named entity 'EGGS' named entity 'CHICKEN' named entity 'CAPABLE' named entity 'MRNA' named entity 'GUANOSINE' named entity 'LUNGS' named entity 'TO INVESTIGATE' named entity 'DAYS' named entity 'MORBIDITY AND MORTALITY' named entity 'HIGHER' named entity 'PROTECTION' named entity 'FOLLOWING' named entity 'EMBRYONIC' named entity 'INFECTION INDUCED' named entity 'SURVIVAL RATES' named entity 'RESPIRATORY TRACT' named entity 'IMMUNE CELLS' named entity 'MAY BE' named entity 'CYTOSINE' named entity 'INFECTION' named entity 'INFERRED' named entity 'MECHANISMS' named entity 'ENHANCED' named entity 'TOLL-LIKE RECEPTOR' named entity 'infection' named entity 'guanosine' named entity 'embryo'

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