About: Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus

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About: Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus
Creator	Weber, Friedemann Spiegel, Martin
Source	Medline; PMC
abstract	BACKGROUND: SARS coronavirus (SARS-CoV) is the etiologic agent of the severe acute respiratory syndrome. SARS-CoV mainly infects tissues of non-lymphatic origin, and the cytokine profile of those cells can determine the course of disease. Here, we investigated the cytokine response of two human non-lymphatic cell lines, Caco-2 and HEK 293, which are fully permissive for SARS-CoV. RESULTS: A comparison with established cytokine-inducing viruses revealed that SARS-CoV only weakly triggered a cytokine response. In particular, SARS-CoV did not activate significant transcription of the interferons IFN-α, IFN-β, IFN-λ1, IFN-λ2/3, as well as of the interferon-induced antiviral genes ISG56 and MxA, the chemokine RANTES and the interleukine IL-6. Interestingly, however, SARS-CoV strongly induced the chemokines IP-10 and IL-8 in the colon carcinoma cell line Caco-2, but not in the embryonic kidney cell line 293. CONCLUSION: Our data indicate that SARS-CoV suppresses the antiviral cytokine system of non-immune cells to a large extent, thus buying time for dissemination in the host. However, synthesis of IP-10 and IL-8, which are established markers for acute-stage SARS, escapes the virus-induced silencing at least in some cell types. Therefore, the progressive infiltration of immune cells into the infected lungs observed in SARS patients could be due to the production of these chemokines by the infected tissue cells.
has issue date	2006-03-29(xsd:dateTime)
bibo:doi	10.1186/1743-422x-3-17
bibo:pmid	16571117
has license	cc-by
sha1sum (hex)	4fa871503ddbbaaead7a34fce89298a36648f662
schema:url	https://doi.org/10.1186/1743-422x-3-17
resource representing a document's title	Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus
has PubMed Central identifier	PMC1444920
has PubMed identifier	16571117
schema:publication	Virol J
resource representing a document's body	covid:4fa871503ddbbaaead7a34fce89298a36648f662#body_text
is schema:about of	named entity 'GENE EXPRESSION' named entity 'NON-' named entity 'INHIBITION' named entity 'VIROLOGY' named entity 'GENES' named entity 'JOURNAL ' named entity 'CELLS' covid:arg/4fa871503ddbbaaead7a34fce89298a36648f662 named entity 'INFECTS' named entity 'SARS CORONAVIRUS' named entity 'CHEMOKINE' named entity 'INFECTED' named entity 'CYTOKINE GENE' named entity 'HUMAN' named entity 'SARS CORONAVIRUS' named entity 'CELLS' named entity 'DISEASE' named entity 'CELL LINES' named entity 'DETERMINE' named entity 'CYTOKINE ' named entity 'CACO-2' named entity 'NON-' named entity 'CYTOKINE PROFILE' named entity 'HERE' named entity 'HEK 293' named entity 'RESPONSE' named entity 'LYMPHATIC' named entity 'FULLY' named entity 'COURSE' named entity 'INVESTIGATED' named entity 'ORIGIN' named entity 'ETIOLOGIC AGENT' named entity 'INDUCTION' named entity 'LYMPHATIC' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'TISSUES' named entity 'BACKGROUND' named entity 'SARS-COV' named entity 'SARS-CoV' named entity 'SARS coronavirus' named entity 'expression' named entity 'cell lines' named entity 'SARS-CoV' named entity 'HEK 293' named entity 'SARS-CoV' named entity 'cell type' named entity 'HEK 293 cells' named entity 'China' named entity 'virus' named entity 'cell line' named entity 'mRNA' named entity 'clinical outcome' named entity 'SARS-CoV' named entity 'IL-8' named entity 'lungs' named entity 'cytokines' named entity 'immune-mediated' named entity 'cytokines' named entity 'infection' named entity 'SARS-CoV' named entity 'cytokine' named entity 'cell lines' named entity 'virus' named entity 'IL-6' named entity 'SARS' named entity 'viruses' named entity 'SARS-CoV' named entity 'RANTES' named entity 'SARS-CoV' named entity 'immune cells' named entity 'gene' named entity 'IL-8' named entity 'viruses' named entity 'tissue cells' named entity 'reverse transcriptase' named entity 'Huh7' named entity 'IL-8' named entity 'actin' named entity 'IL-6' named entity 'IP-10'

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