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About:
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection
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An Entity of Type :
schema:ScholarlyArticle
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covidontheweb.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection
Creator
Nguyen-Van-Tam, Jonathan
Enstone, Joanne
Nicholson, Karl
Bannister, Barbara
Read, Robert
Openshaw, Peter
Myles, Puja
Brett, Stephen
Taylor, Bruce
Lim, Wei
Semple, Malcolm
Mcmenamin ##, Jim
source
Medline; PMC
abstract
Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared with nonasthmatics. The reasons for this are unknown. We performed a retrospective analysis of data on 1520 patients admitted to 75 UK hospitals with confirmed influenza A/H1N1 2009 infection. A multivariable model was used to investigate reasons for the association between asthma and severe outcomes (intensive care unit support or death). Asthmatics were less likely than nonasthmatics to have severe outcome (11.2% versus 19.8%, unadjusted OR 0.51, 95% CI 0.36–0.72) despite a greater proportion requiring oxygen on admission (36.4% versus 26%, unadjusted OR 1.63) and similar rates of pneumonia (17.1% versus 16.6%, unadjusted OR 1.04). The results of multivariable logistic regression suggest the association of asthma with outcome (adjusted OR 0.62, 95% CI 0.36–1.05; p=0.075) are explained by pre-admission inhaled corticosteroid use (adjusted OR 0.34, 95% CI 0.18–0.66) and earlier admission (≤4 days from symptom onset) (adjusted OR 0.60, 95% CI 0.38–0.94). In asthmatics, systemic corticosteroids were associated with a decreased likelihood of severe outcomes (adjusted OR 0.36, 95% CI 0.18–0.72). Corticosteroid use and earlier hospital admission explained the association of asthma with less severe outcomes in hospitalised patients.
has issue date
2012-08-16
(
xsd:dateTime
)
bibo:doi
10.1183/09031936.00015512
bibo:pmid
22903963
has license
cc-by-nc
sha1sum (hex)
4f8d0dce755f89c22c48c301fe55a457c8ed715b
schema:url
https://doi.org/10.1183/09031936.00015512
resource representing a document's title
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection
has PubMed Central identifier
PMC3612580
has PubMed identifier
22903963
schema:publication
Eur Respir J
resource representing a document's body
covid:4f8d0dce755f89c22c48c301fe55a457c8ed715b#body_text
is
schema:about
of
named entity 'INFECTION'
named entity 'INTENSIVE CARE'
named entity 'INFECTION'
named entity 'REASONS'
named entity 'DIE'
named entity 'INFLUENZA A'
named entity 'COMPARED'
named entity 'UNKNOWN'
named entity 'LIKELY'
named entity 'INFLUENZA A'
named entity 'ASTHMATICS'
named entity 'ASTHMATICS'
covid:arg/4f8d0dce755f89c22c48c301fe55a457c8ed715b
named entity 'infection'
named entity 'infection'
named entity 'infection'
named entity 'Asthmatics'
named entity 'asthmatics'
named entity 'influenza A'
named entity 'intensive care'
named entity 'asthmatics'
named entity 'asthma'
named entity 'dyspnoea'
named entity 'asthma'
named entity 'Confidentiality'
named entity 'risk of death'
named entity 'virus'
named entity 'symptom'
named entity 'antiviral'
named entity 'adequately powered'
named entity 'clinical surveillance'
named entity 'symptom'
named entity 'corticosteroid'
named entity 'long-term'
named entity 'asthma'
named entity 'asthma'
named entity 'risk factors'
named entity 'inflammation'
named entity 'asthmatics'
named entity 'asthma'
named entity 'corticosteroid'
named entity 'corticosteroid'
named entity 'asthma'
named entity 'public health surveillance'
named entity 'inhaled corticosteroids'
named entity 'current dataset'
named entity 'consciousness'
named entity 'influenza infection'
named entity 'oseltamivir'
named entity 'asthmatics'
named entity 'asthma'
named entity 'respiratory compromise'
named entity 'inhaled steroid'
named entity 'chest radiograph'
named entity 'respiratory compromise'
named entity 'symptom'
named entity 'respiratory viral infections'
named entity 'asthma'
named entity '2.11'
named entity 'intravenous'
named entity 'chest radiograph'
named entity 'antiviral'
named entity 'rhinovirus'
named entity 'corticosteroids'
named entity 'influenza vaccination'
named entity 'infection'
named entity 'asthma'
named entity 'Charlson index'
named entity 'asthma'
named entity 'respiratory distress'
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