About: High‐cell‐passage canine coronavirus vaccine providing sterilising immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High‐cell‐passage canine coronavirus vaccine providing sterilising immunity
Creator	Pratelli, A
Source	Medline; PMC
abstract	Objectives: To evaluate the ability of a high‐cell‐passage canine coronavirus vaccine to immunise dogs against challenge with a field isolate of the virus. Methods: Three dogs that had previously tested seronegative and virus‐negative for canine coronavirus were inoculated twice, at 21‐day intervals, with the vaccine and kept under observation. Two seronegative and virus‐negative dogs served as unvaccinated controls. For safety tests, two additional dogs were inoculated oronasally with 10 times the vaccinal dose and no reactions were observed. Faecal samples were collected daily from the vaccinated dogs after the first and second inoculations. Both vaccinated and control dogs were challenged two weeks after the second vaccination with a field canine coronavirus strain. Blood samples were collected for serological tests before vaccination and at weekly intervals after vaccinations and challenge. Results: Virus was not detected in faecal samples after the first or second vaccinations by virus isolation assays and PCR. Significantly, the vaccinated dogs did not have clinical signs after challenge and no virus shedding was observed. The two unvaccinated control dogs had moderate enteritis, and virus was detected in cell cultures starting from three days postchallenge (dog 1) and two days postchallenge (dog 2), and by PCR for 23 median days. Clinical Significance: This study showed the efficacy of a high‐cell‐passage canine coronavirus vaccine in preventing infection of dogs by virulent virus and, specifically, its ability to induce sterilising immunity.
has issue date	2007-09-14(xsd:dateTime)
bibo:doi	10.1111/j.1748-5827.2007.00416.x
bibo:pmid	17877547
has license	no-cc
sha1sum (hex)	4f7c0df011e53936b93f38aabee187cf6f202a99
schema:url	https://doi.org/10.1111/j.1748-5827.2007.00416.x
resource representing a document's title	High‐cell‐passage canine coronavirus vaccine providing sterilising immunity
has PubMed Central identifier	PMC7167119
has PubMed identifier	17877547
schema:publication	J Small Anim Pract
resource representing a document's body	covid:4f7c0df011e53936b93f38aabee187cf6f202a99#body_text
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