About: Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

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About: Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia
Creator	Becker, Stephan Herold, Susanne Peteranderl, Christin Hocke, Andreas Opitz, Bastian Suttorp, Norbert Baal, Nelli Brack, Markus Chaput, Catherine Dietert, Kristina Gutbier, Birgitt Hackstein, Holger Jiang, Xiaohui Kupke, Alexandra Naujoks, Jan Reppe, Katrin Slevogt, Hortense Witzenrath, Martin Yao, Ling Gruber, Achim Sander, Leif Wienhold, Sandra Von Lachner, Carolin
Source	Medline; PMC
abstract	Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.
has issue date	2017-11-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0188251
bibo:pmid	29155867
has license	cc-by
sha1sum (hex)	4f4a156d0bc65afd5d8f5b80b4bb8436a590955a
schema:url	https://doi.org/10.1371/journal.pone.0188251
resource representing a document's title	Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia
has PubMed Central identifier	PMC5695780
has PubMed identifier	29155867
schema:publication	PLoS One
resource representing a document's body	covid:4f4a156d0bc65afd5d8f5b80b4bb8436a590955a#body_text
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