About: SARS-CoV-2-mediated encephalitis: role of AT2R receptors in the blood-brain barrier

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About: SARS-CoV-2-mediated encephalitis: role of AT2R receptors in the blood-brain barrier Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2-mediated encephalitis: role of AT2R receptors in the blood-brain barrier
Creator	Magalhães, De Barbosa, A Barbosa, Reis Dos, Jayro Ferreira, Santos Kleiton De Sousa, Antônio Luiz, André
Source	Elsevier; PMC
abstract	At the end of 2019, there was an outbreak of a new Coronavirus 2019 (COVID-19 disease). Studies suggest that SARS-CoV-2 can cause infection in the central nervous system (CNS) and trigger neurological symptoms that include headache, nausea and vomiting, mental confusion and loss of smell or taste. These findings reveal that Coronaviruses have neurological tropism and neuroinvasive capacity. The spread of SARS-CoV-2 in the brain tissue possibly occurs through the systemic circulation as reported in patients affected by SARS-CoV. Evidence highlights similarity between the SARS-CoV genome and SARS-CoV-2 and that both interact with the angiotensin-converting enzyme type 2 (ACE2) located in the brain tissue of infected patients. Hence, the presence of ACE2 is likely in the CNS to mediate the entry of the SARS-CoV-2 virus into neural tissue. Our hypothesis suggests that SARS-CoV-2 can cause encephalitis through the production of inflammatory mediators and activation of immune system cells resulting from the interaction of the ACE2 receptor with the viral Spike protein that causes an increase in angiotensin II. This mechanism has the ability to activate immune system cells by exacerbating stimuli at the angiotensin 2 receptor (AT2R). Thus, it leads to a status of brain injury preceded by vascular damage and destruction of the blood-brain barrier, making it responsible for the installation of acute inflammation.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.110213
has license	no-cc
sha1sum (hex)	4eeebd156da2b87892166cf3bc2323cf3ce25d61
schema:url	https://doi.org/10.1016/j.mehy.2020.110213
resource representing a document's title	SARS-CoV-2-mediated encephalitis: role of AT2R receptors in the blood-brain barrier
has PubMed Central identifier	PMC7449115
schema:publication	Med Hypotheses
resource representing a document's body	covid:4eeebd156da2b87892166cf3bc2323cf3ce25d61#body_text
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