About: The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis

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About: The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis
Creator	Hu, Yoonsung Park, Nogi Rego, Sara Yoon, Sunghyun Doran, Kelly Spencer, Brady Thornton, Justin Deng Id, Liwen Holmes Id, Joshua Id, Rong Id, Seo Id, Thomas Jenkinson Id, Howard Nagao Id, Prescilla Nobbs Id, Angela Sanches Id, Glenda Seok, Keun
Source	PMC
abstract	Streptococcus agalactiae (Group B Streptococcus, GBS) normally colonizes healthy adults but can cause invasive disease, such as meningitis, in the newborn. To gain access to the central nervous system, GBS must interact with and penetrate brain or meningeal blood vessels; however, the exact mechanisms are still being elucidated. Here, we investigate the contribution of BspC, an antigen I/II family adhesin, to the pathogenesis of GBS meningitis. Disruption of the bspC gene reduced GBS adherence to human cerebral microvascular endothelial cells (hCMEC), while heterologous expression of BspC in non-adherent Lactococcus lactis conferred bacterial attachment. In a murine model of hematogenous meningitis, mice infected with ΔbspC mutants exhibited lower mortality as well as decreased brain bacterial counts and inflammatory infiltrate compared to mice infected with WT GBS strains. Further, BspC was both necessary and sufficient to induce neutrophil chemokine expression. We determined that BspC interacts with the host cytoskeleton component vimentin and confirmed this interaction using a bacterial two-hybrid assay, microscale thermophoresis, immunofluorescent staining, and imaging flow cytometry. Vimentin null mice were protected from WT GBS infection and also exhibited less inflammatory cytokine production in brain tissue. These results suggest that BspC and the vimentin interaction is critical for the pathogenesis of GBS meningitis.
has issue date	2019-06-10(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1007848
bibo:pmid	31181121
has license	cc-by
sha1sum (hex)	4ee3d76ee71e4eac590b1b228fc72dc372cdc16f
schema:url	https://doi.org/10.1371/journal.ppat.1007848
resource representing a document's title	The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis
has PubMed Central identifier	PMC6586375
has PubMed identifier	31181121
schema:publication	PLoS Pathog
resource representing a document's body	covid:4ee3d76ee71e4eac590b1b228fc72dc372cdc16f#body_text
is schema:about of	named entity 'adhesin' named entity 'vimentin' named entity 'GBS' named entity 'central nervous system' named entity 'immunofluorescent' named entity 'reduced' named entity 'brain' named entity 'BRAIN ENDOTHELIUM' named entity 'SURFACE ANTIGEN' named entity 'ADHERENCE' covid:arg/4ee3d76ee71e4eac590b1b228fc72dc372cdc16f named entity 'MICROVASCULAR' named entity 'BACTERIAL TWO-HYBRID' named entity 'ANTIGEN' named entity 'TWO-HYBRID ASSAY' named entity 'INVESTIGATE' named entity 'MODEL OF' named entity 'PENETRATE' named entity 'FAMILY' named entity 'INTERACT' named entity 'MICE' named entity 'THESE' named entity 'MICROSCALE THERMOPHORESIS' named entity 'EXACT' named entity 'RESULTS' named entity 'HEALTHY' named entity 'CONTRIBUTION' named entity 'INDUCE' named entity 'COMPARED' named entity 'INFLAMMATORY INFILTRATE' named entity 'EXPRESSION' named entity 'BLOOD VESSELS' named entity 'BEING' named entity 'BRAIN TISSUE' named entity 'MUTANTS' named entity 'MORTALITY' named entity 'ACCESS' named entity 'ADHERENCE' named entity 'GAIN' named entity 'VIMENTIN' named entity 'HOST CYTOSKELETON' named entity 'BACTERIAL' named entity 'ADULTS' named entity 'DISRUPTION' named entity 'CAUSE' named entity 'NEWBORN' named entity 'LOWER' named entity 'DECREASED' named entity 'HEMATOGENOUS' named entity 'INVASIVE DISEASE' named entity 'NULL MICE' named entity 'DETERMINED' named entity 'BUT' named entity 'GBS' named entity 'STREPTOCOCCUS' named entity 'PROMOTE' named entity 'MENINGITIS' named entity 'PROTEIN' named entity 'AUTHOR' named entity 'VIMENTIN' named entity 'INFLAMMATION' named entity 'IMAGING FLOW CYTOMETRY' named entity 'BACTERIAL COUNTS' named entity 'STREPTOCOCCUS AGALACTIAE' named entity 'MENINGITIS'

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