About: Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair

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About: Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair
Creator	Kashanchi, Fatah El-Hage, Nazira Liotta, Lance Agbottah, Emmanuel Branscome, Heather Paul, Siddhartha Yin, Dezhong Zadeh, Mohammad Alonso-Martin, Sonia Corradetti, Bruna Krämer-Albers, Eva-Maria
Source	Medline; PMC
abstract	Neurodegeneration is a hallmark of many diseases and disorders of the central nervous system (CNS). High levels of neuroinflammation are often associated with irreparable damage to CNS cells due to the dysregulation of signaling cascades that are unable to restore a homeostatic balance. Due to the inherent complexity of the CNS, development of CNS-related therapeutics has met limited success. While stem cell therapy has been evaluated in the context of CNS repair, the mechanisms responsible for their functional properties have not been clearly defined. In recent years, there has been growing interest in the use of stem cell extracellular vesicles (EVs) for the treatment of various CNS pathologies as these vesicles are believed to mediate many of the functional effects associated with their donor stem cells. The potency of stem cell EVs is believed to be largely driven by their biological cargo which includes various types of RNAs, proteins, and cytokines. In this review, we describe the characteristic properties of stem cell EVs and summarize their reported neuroprotective and immunomodulatory functions. A special emphasis is placed on the identification of specific biological cargo, including proteins and non-coding RNA molecules, that have been found to be associated with stem cell EVs. Collectively, this review highlights the potential of stem cell EVs as an alternative to traditional stem cell therapy for the repair of cellular damage associated with diverse CNS pathologies.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.3389/fcell.2020.00455
bibo:pmid	32587858
has license	cc-by
sha1sum (hex)	4ea2036823092b2e00969d22180f4456e11acd1b
schema:url	https://doi.org/10.3389/fcell.2020.00455
resource representing a document's title	Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair
has PubMed Central identifier	PMC7298153
has PubMed identifier	32587858
schema:publication	Front Cell Dev Biol
resource representing a document's body	covid:4ea2036823092b2e00969d22180f4456e11acd1b#body_text
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