About: Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department

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About: Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department
Creator	Lee, Tae So, Hwan Yu, Taek
source	Medline; PMC
abstract	BACKGROUND: Fever is a common cause of pediatric consultation in the emergency department. However, identifying the source of infection in many febrile infants is challenging because of insufficient presentation of signs and symptoms. Meningitis is a critical cause of fever in infants, and its diagnosis is confirmed invasively by lumbar puncture. This study aimed to evaluate potential laboratory markers for meningitis in febrile infants. METHODS: We retrospectively analyzed infants aged <3 months who visited the emergency department of our hospital between May 2012 and May 2017 because of fever of unknown etiology. Clinical information and laboratory data were evaluated. Receiver operating characteristic (ROC) curves were constructed. RESULTS: In total, 145 febrile infants aged <3 months who underwent lumbar punctures were evaluated retrospectively. The mean C-reactive protein (CRP) level was significantly higher in the meningitis group than in the non-meningitis group, whereas the mean white blood cell count or absolute neutrophil count (ANC) did not significantly differ between groups. The area under the ROC curve (AUC) for CRP was 0.779 (95% confidence interval [CI], 0.701–0.858). The AUC for the leukocyte count was 0.455 (95% CI, 0.360–0.550) and that for ANC was 0.453 (95% CI, 0.359–0.547). The CRP cut-off value of 10 mg/L was optimal for identifying possible meningitis. CONCLUSION: CRP has an intrinsic predictive value for meningitis in febrile infants aged <3 months. Despite its invasiveness, a lumbar puncture may be recommended to diagnose meningitis in young, febrile infants with a CRP level >10 mg/L.
has issue date	2020-01-08(xsd:dateTime)
bibo:doi	10.12701/yujm.2019.00402
bibo:pmid	31914719
has license	cc-by-nc
sha1sum (hex)	4e8cbb254d84091bc1737f77d0076709d83de9ad
schema:url	https://doi.org/10.12701/yujm.2019.00402
resource representing a document's title	Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department
has PubMed Central identifier	PMC7142029
has PubMed identifier	31914719
schema:publication	Yeungnam Univ J Med
resource representing a document's body	covid:4e8cbb254d84091bc1737f77d0076709d83de9ad#body_text
is schema:about of	named entity 'level' named entity 'critical' named entity 'absolute neutrophil count' named entity 'laboratory' named entity 'Meningitis' named entity 'meningitis' named entity 'retrospectively' named entity 'lumbar puncture' named entity 'AUC' named entity 'Methods' named entity 'higher' named entity 'confirmed' named entity 'predictive' named entity 'meningitis' named entity '2017' named entity 'infants' named entity 'METHODS' named entity 'AGED' named entity 'TOTAL' named entity 'This' named entity 'CRP' named entity 'area' named entity 'febrile' named entity 'infants' named entity 'symptoms' named entity 'The' named entity 'white blood cell' named entity 'confidence interval' named entity 'emergency department' named entity 'potential' named entity 'Germany' named entity 'etiology' named entity 'CSF analysis' named entity 'count' named entity 'aged' named entity 'evaluate' named entity 'presentation' named entity 'diagnosis' named entity 'emergency department' named entity 'ROC' named entity 'febrile' named entity 'lumbar puncture' named entity 'Receiver operating characteristic' named entity 'AUC' named entity 'pediatric' named entity '95% CI' named entity 'ANC' named entity 'meningitis' named entity 'emergency department' named entity 'multiplex PCR' named entity 'Korea' named entity 'vomiting' named entity 'pathogens' named entity 'Rotavirus' named entity 'headache' named entity 'meningitis' named entity 'ROC' named entity 'sensitivity, specificity' named entity 'blood culture' named entity 'neonates' named entity 'CRP' named entity 'cut-off' named entity 'NPV' named entity 'CRP' named entity 'aseptic' named entity 'febrile' named entity 'emergency department' named entity 'meningitis' named entity 'St. Ingbert' named entity 'statistically significant' named entity 'blood culture' named entity 'assay' named entity 'WBC' named entity 'meningitis' named entity 'liver' named entity 'bacterial infection' named entity 'fever' named entity 'ANC' named entity 'p-value'

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