About: New Advances in CNS Immunity against Viral Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New Advances in CNS Immunity against Viral Infection
Creator	Manglani, Monica Mcgavern, Dorian
Source	Elsevier; Medline; PMC
abstract	The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from executive to autonomic. Despite these barriers, the CNS can be infected through several entry portals, giving rise to meningitis and encephalitis. Following infection, resident cells recruit peripherally-derived immune cells to sites of viral infection. In this review, we discuss recent advances in immune recruitment and entry at barrier structures as well as current immunotherapeutic strategies for the treatment of persistent viral infections.
has issue date	2018-02-01(xsd:dateTime)
bibo:doi	10.1016/j.coviro.2017.12.003
bibo:pmid	29289900
has license	green-oa
sha1sum (hex)	4e85c20dbbcdf9c1fa08d33a979fe70b48c5b05b
schema:url	https://doi.org/10.1016/j.coviro.2017.12.003
resource representing a document's title	New Advances in CNS Immunity against Viral Infection
has PubMed Central identifier	PMC5990251
has PubMed identifier	29289900
schema:publication	Current Opinion in Virology
resource representing a document's body	covid:4e85c20dbbcdf9c1fa08d33a979fe70b48c5b05b#body_text
is schema:about of	named entity 'VIRAL INFECTION' named entity 'NEW' named entity 'IMMUNITY' named entity 'CNS' named entity 'immunity' named entity 'CNS' named entity 'CNS' named entity 'pericytes' named entity 'astrocytes' named entity 'JCV' named entity 'CD8 +' named entity 'HSV-1' named entity 'immune responses' named entity 'pathogen' named entity 'virus' named entity 'genomic evolution' named entity 'olfactory epithelium' named entity 'neurotropic' named entity 'Immune cells' named entity 'CNS' named entity 'adoptive immunotherapy' named entity 'blood vessels' named entity 'adaptive immune cells' named entity 'fenestrated' named entity 'viral persistence' named entity 'CNS' named entity 'virus' named entity 'mice' named entity 'blood-brain barrier' named entity 'apoptosis' named entity 'CNS' named entity 'pia mater' named entity 'blood vessels' named entity 'case report' named entity 'viral entry' named entity 'CXCL9' named entity 'CSF' named entity 'viral protein' named entity 'infectious diseases' named entity 'viruses' named entity 'specific immunity' named entity 'CCL5' named entity 'CNS' named entity 'CNS' named entity 'neurons' named entity 'choroid plexus' named entity 'CNS' named entity 'viral infection' named entity 'neuroinflammation' named entity 'viruses' named entity 'CD8 +' named entity 'deep cervical lymph nodes' named entity 'macrophages' named entity 'interact' named entity 'microglia' named entity 'inflammation' named entity 'meningoencephalitis' named entity 'immune-privileged' named entity 'HIV-1' named entity 'antiviral' named entity 'CSF' named entity 'tight junctions' named entity 'immune cell' named entity 'meninges' named entity 'neurons' named entity 'antiviral' named entity 'solutes' named entity 'ISGs' named entity 'MRI' named entity 'inflammation' named entity 'immunotherapy' named entity 'immune cells' named entity 'JCV' named entity 'CNS' named entity 'brain and spinal cord' named entity 'Microglia' named entity 'treat patients' named entity 'infection' named entity 'CNS' named entity 'VSV'

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