About: Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality

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About: Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality
Creator	Spain, Sureda, Anna Bladé, Joan Blanchard, María Caminos, Nerea Casado, Luis Cb16, / Conde, Diego De La Cruz, Javier De La Puerta, José Encinas, Cristina Escalante, Fernando Fernández De Larrea, Carlos Giménez, Eugenio Gironella, Mercedes Grau, Rosalía Krsnik, Isabel Lahuerta, Juan López De La Guía, Ana Martínez-Barranco, Pilar Martínez-López, Joaquín Mateos, Juan Mateos, María-Victoria Pamplona, Prieto, Elena San-Miguel, Jesús Senin, María
Source	MedRxiv
abstract	There is limited information on the characteristics, pre-admission prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with coronavirus disease 2019 (COVID-19). This retrospective case series investigated characteristics and outcomes of 167 MM patients hospitalized with COVID-19 reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in Spain between March 1 and April 30, 2020. Outcomes were compared with a randomly selected contemporary cohort of 167 age-/sex-matched non-cancer patients with COVID-19 admitted at 6 participating hospitals. Common demographic, clinical, laboratory, treatment, and outcome variables were collected; specific disease status and treatment data were collected for MM patients. Among the MM and non-cancer patients, median age was 71 years and 57% of patients were male in each series, and 75% and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate-severe in 77% and 89% of patients and critical in 8% and 4%, respectively. Supplemental oxygen was required by 47% and 55% of MM and non-cancer patients, respectively, and 21%/9% vs 8%/6% required non-invasive/invasive ventilation. Inpatient mortality was 34% and 23% in MM and non-cancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors of inpatient mortality on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1101/2020.06.29.20142455
has license	medrxiv
sha1sum (hex)	4e10a65f6c45a2e0d3194268b9943780298a1806
schema:url	https://doi.org/10.1101/2020.06.29.20142455
resource representing a document's title	Multiple Myeloma and SARS-CoV-2 Infection: Clinical Characteristics and Prognostic Factors of Inpatient Mortality
resource representing a document's body	covid:4e10a65f6c45a2e0d3194268b9943780298a1806#body_text
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