About: Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences
Creator	Butowt, Rafal Von Bartheld, Christopher Hagen, Molly
topic	covid:4df759a9a46dd00300ddb41fc7d3c1cb46d8ca71#this
Source	MedRxiv; Medline; PMC
abstract	A significant fraction of people who test positive for COVID-19 have chemosensory deficits. However, the reported prevalence of these deficits in smell and/or taste varies widely, and the reason for the differences between studies is unclear. We determined the pooled prevalence of such chemosensory deficits in a systematic review. We searched the COVID-19 portfolio of the National Institutes of Health for all studies that reported the prevalence of smell and/or taste deficits in patients diagnosed with COVID-19. Forty-two studies reporting on 23,353 patients qualified and were subjected to a systematic review and meta-analysis. Estimated random prevalence of olfactory dysfunction was 38.5%, of taste dysfunction was 30.4% and of overall chemosensory dysfunction was 50.2%. We examined the effects of age, disease severity, and ethnicity on chemosensory dysfunction. The effect of age did not reach significance, but anosmia/hypogeusia decreased with disease severity, and ethnicity was highly significant: Caucasians had a 3-6 times higher prevalence of chemosensory deficits than East Asians. The finding of ethnic differences points to genetic, ethnicity-specific differences of the virus-binding entry proteins in the olfactory epithelium and taste buds as the most likely explanation, with major implications for infectivity, diagnosis and management of the COVID-19 pandemic.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1101/2020.06.15.20132134
bibo:pmid	32587993
has license	cc-by-nd
sha1sum (hex)	4df759a9a46dd00300ddb41fc7d3c1cb46d8ca71
schema:url	https://doi.org/10.1101/2020.06.15.20132134
resource representing a document's title	Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences
has PubMed Central identifier	PMC7310651
has PubMed identifier	32587993
schema:publication	medRxiv
resource representing a document's body	covid:4df759a9a46dd00300ddb41fc7d3c1cb46d8ca71#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/4df759a9a46dd00300ddb41fc7d3c1cb46d8ca71
is schema:about of	named entity 'prevalence' named entity 'disease' named entity 'GENETIC' named entity 'EFFECT' named entity 'SIGNIFICANT' named entity 'DYSFUNCTION' named entity 'RANDOM' named entity 'VARIES' named entity 'DIAGNOSED WITH COVID-19' named entity 'NATIONAL INSTITUTES OF HEALTH' named entity 'SMELL' named entity 'EFFECTS' named entity 'ANOSMIA' named entity 'MAJOR' named entity 'OLFACTORY EPITHELIUM' named entity 'HAVE' named entity 'DID' named entity 'MANAGEMENT' named entity 'portfolio' named entity 'prevalence' named entity 'taste buds' named entity 'chemosensory' named entity 'dysfunction' named entity 'systematic review' named entity 'systematic review' named entity 'Institutes' named entity 'Health' named entity 'test' named entity '6 times' named entity 'olfactory dysfunction' named entity 'systematic review' named entity 'anosmia' named entity 'chemosensory' named entity '23,353' named entity 'chemosensory' named entity 'COVID-19' named entity 'taste buds' named entity 'virus' named entity 'Ethnic Differences' named entity 'Prevalence' named entity 'meta-analysis' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'chemosensory' named entity 'COVID-19' named entity 'COVID-19' named entity 'medRxiv' named entity 'Moein' named entity 'chemosensory' named entity 'North America' named entity 'data collection' named entity 'sample size' named entity 'respiratory epithelium' named entity 'medRxiv' named entity 'COVID-19' named entity 'chemosensory' named entity 'COVID-19' named entity 'significant difference' named entity 'Olfaction' named entity 'East Asians' named entity 'anosmia' named entity 'medRxiv' named entity 'confidence intervals' named entity 'peer review' named entity 'ethnicity' named entity 'chemosensory' named entity 'inflammation' named entity 'Korea' named entity 'Europe' named entity 'loss of smell' named entity 'COVID-19' named entity 'CC-BY-NC 4.0' named entity 'sensory function' named entity 'chemosensory' named entity 'logit transformation' named entity 'Austria' named entity 'medRxiv'

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