About: Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces

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About: Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces
Creator	Miller, David Altamura, Louis Biryukov, Jennifer Boydston, Jeremy Dabisch, Paul Dawson, David Freeburger, Denise Hevey, Michael Hooper, Idris Krause, Melissa Ratnesar-Shumate, Shanna Wahl, Victoria Williams, Gregory Wood, Stewart Yeager, John Yolitz, Jason Zeitouni, Nathalie Dunning, Rebecca Ferris, Allison Herzog, Artemas Phillips, Aaron Reese, Amy Weaver, Wade
source	Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) was first identified in China in late 2019 and is caused by newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Previous studies had reported the stability of SARS-CoV-2 in cell culture media and deposited onto surfaces under a limited set of environmental conditions. Here, we broadly investigated the effects of relative humidity, temperature, and droplet size on the stability of SARS-CoV-2 in a simulated clinically relevant matrix dried on nonporous surfaces. The results show that SARS-CoV-2 decayed more rapidly when either humidity or temperature was increased but that droplet volume (1 to 50 μl) and surface type (stainless steel, plastic, or nitrile glove) did not significantly impact decay rate. At room temperature (24°C), virus half-life ranged from 6.3 to 18.6 h depending on the relative humidity but was reduced to 1.0 to 8.9 h when the temperature was increased to 35°C. These findings suggest that a potential for fomite transmission may persist for hours to days in indoor environments and have implications for assessment of the risk posed by surface contamination in indoor environments. IMPORTANCE Mitigating the transmission of SARS-CoV-2 in clinical settings and public spaces is critically important to reduce the number of COVID-19 cases while effective vaccines and therapeutics are under development. SARS-CoV-2 transmission is thought to primarily occur through direct person-to-person transfer of infectious respiratory droplets or through aerosol-generating medical procedures. However, contact with contaminated surfaces may also play a significant role. In this context, understanding the factors contributing to SARS-CoV-2 persistence on surfaces will enable a more accurate estimation of the risk of contact transmission and inform mitigation strategies. To this end, we have developed a simple mathematical model that can be used to estimate virus decay on nonporous surfaces under a range of conditions and which may be utilized operationally to identify indoor environments in which the virus is most persistent.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1128/msphere.00441-20
bibo:pmid	32611701
has license	cc-by
sha1sum (hex)	4dce50cb5e21b9be7736e9d0d226616aff0f8ab4
schema:url	https://doi.org/10.1128/msphere.00441-20
resource representing a document's title	Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces
has PubMed Central identifier	PMC7333574
has PubMed identifier	32611701
schema:publication	mSphere
resource representing a document's body	covid:4dce50cb5e21b9be7736e9d0d226616aff0f8ab4#body_text
is schema:about of	named entity 'surfaces' named entity 'Here' named entity 'transmission' named entity 'environments' named entity 'direct' named entity 'surface' named entity 'simulated' named entity 'inform' named entity 'virus' named entity 'rapidly' named entity 'nonporous' named entity 'days' named entity 'SARS-CoV-2' named entity 'matrix' named entity 'Temperature' named entity 'CONTAMINATED' named entity 'HUMIDITY' named entity 'CORONAVIRUS DISEASE 2019' named entity 'CONTRIBUTING' named entity 'SIGNIFICANT' named entity 'NITRILE' named entity 'SARS-COV-2 TRANSMISSION' named entity 'CASES' named entity 'RISK' named entity 'DIRECT' named entity 'LIMITED' named entity 'STRATEGIES' named entity 'VACCINES' named entity 'SURFACES' named entity 'LATE' named entity 'decay rate' named entity 'effective' named entity 'number' named entity 'China' named entity 'public spaces' named entity 'assessment' named entity 'estimate' named entity 'therapeutics' named entity 'relative humidity' named entity 'droplet' named entity 'environments' named entity 'culture media' named entity 'transmission' named entity 'plastic' named entity 'relative humidity' named entity 'assessment of the risk' named entity 'nonporous' named entity 'vaccines' named entity 'decay rate' named entity 'SARS-CoV-2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'half-life' named entity 'cell culture media' named entity 'SARS-CoV-2' named entity 'humidity' named entity 'volume' named entity 'one-way analysis of variance' named entity 'stainless steel' named entity 'acrylonitrile butadiene styrene'

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