About: CD8 memory T cells: cross-reactivity and heterologous immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD8 memory T cells: cross-reactivity and heterologous immunity
Creator	Calcagno, Claudia Celada, Franco Cornberg, Markus Ghersi, Dario Kim, Sung-Kwon Puzone, Roberto Brehm, Michael Selin, Liisa Welsh, Raymond
Source	Elsevier; Medline; PMC
abstract	Abstract Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.
has issue date	2004-10-31(xsd:dateTime)
bibo:doi	10.1016/j.smim.2004.08.014
bibo:pmid	15528078
has license	els-covid
sha1sum (hex)	4dc5e0ae0faadc9e77cd804e89e21d0933e88c77
schema:url	https://doi.org/10.1016/j.smim.2004.08.014
resource representing a document's title	CD8 memory T cells: cross-reactivity and heterologous immunity
has PubMed Central identifier	PMC7128110
has PubMed identifier	15528078
schema:publication	Seminars in Immunology
resource representing a document's body	covid:4dc5e0ae0faadc9e77cd804e89e21d0933e88c77#body_text
is schema:about of	named entity 'survival' named entity 'immune responses' named entity 'PROTECTIVE IMMUNITY' named entity 'EMPLOYED' named entity 'CONSEQUENCE OF' named entity 'MEMORY T CELL' named entity 'NUMEROUS' named entity 'MODELS' named entity 'THEIR' named entity 'NEW' named entity 'IMMUNE RESPONSES' named entity 'POOL' named entity 'MEDIATE' named entity 'ANTIGEN RECOGNITION' named entity 'RESPOND TO' named entity 'HOST' named entity 'CD8' named entity 'PLASTICITY' named entity 'FLEXIBILITY' named entity 'T CELL' named entity 'SPECIFIC' named entity 'IMMUNITY' named entity 'CROSS' named entity 'REACTIVITY' named entity 'GRAFT SURVIVAL' named entity 'DYNAMIC' named entity 'POOLS' named entity 'MEMORY T CELLS' named entity 'ALTERED' named entity 'TRANSPLANTATION TOLERANCE' named entity 'VIRUS' named entity 'DISCUSS' named entity 'TO RESPOND' named entity 'LIFE' named entity 'VIRAL PATHOGENESIS' named entity 'MEMORY CELLS' named entity 'INDUCE' named entity 'T CELL IMMUNITY' named entity 'BUT' named entity 'MEMORY T CELLS' named entity 'DIVERSE' named entity 'LARGE' named entity 'MULTITUDE' named entity 'FINITE' named entity 'POPULATIONS' named entity 'PATHOGENS' named entity 'HETEROLOGOUS' named entity 'ANTIGEN' named entity 'HERE' named entity 'MEMORY' named entity 'IMMUNOPATHOLOGY' named entity 'IMMUNE SYSTEM' named entity 'THESE' named entity 'HETEROLOGOUS' named entity 'ALLOW' named entity 'MAINTENANCE' named entity 'accommodate' named entity 'large' named entity 'populations' named entity 'T cell' named entity 'multitude' named entity 'life-threatening' named entity 'memory T cells' named entity 'immunopathology' named entity 'antigen' named entity 'plasticity' named entity 'viral infection' named entity 'C57BL/6' named entity 'infection' named entity 'high affinity' named entity 'clones' named entity 'epitopes' named entity 'clones'

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