About: Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

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About: Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection
Creator	Vaheri, Antti Huhtala, Heini Joutsi-Korhonen, Lotta Laine, Outi Lassila, Riitta Mustonen, Jukka Mäkelä, Satu
Source	Medline; PMC
abstract	We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease. Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus–induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods. The results were related to data on platelet indices and functions, coagulation variables, and clinical disease. Serum TPO was nearly 4-fold higher acutely compared with the control (median 207 pg/mL, range 56–1258 pg/mL vs. median 58 pg/mL, range 11–241 pg/mL, P < 0.001) and coincided with high mean platelet volume (MPV) and immature platelet fraction (IPF%). Prothrombin fragments and D-dimer were high acutely compared with the control (F1 + 2 median 704 pmol/L, range 284–1875 pmol/L vs. median 249 pmol/L, range 118–556 pmol/L, P < 0.001; d-dimer median 2.8 mg/L, range 0.6–34.0 mg/L vs. median 0.4 mg/L, range 0.2–1.1 mg/L, P < 0.001), and associated with low platelet count and severe acute kidney injury (AKI). MPs’ procoagulant activity was high acutely only among patients with mild AKI (plasma creatinine below the median at the time of the measurement). Upregulated TPO together with high MPV and IPF% confirm active thrombopoiesis, but do not predict severity of HFRS. Simultaneously, elevated prothrombin fragments and d-dimer suggest increased consumption of platelets in patients with severe AKI. Activity of platelet-derived MPs in HFRS should be studied with flow cytometry in a larger cohort of patients.
has issue date	2016-12-30(xsd:dateTime)
bibo:doi	10.1097/md.0000000000005689
bibo:pmid	28033261
has license	cc-by-nc
sha1sum (hex)	4db442dee5f7675795f576b1f6b7be277decf03b
schema:url	https://doi.org/10.1097/md.0000000000005689
resource representing a document's title	Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection
has PubMed Central identifier	PMC5207557
has PubMed identifier	28033261
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:4db442dee5f7675795f576b1f6b7be277decf03b#body_text
is schema:about of	named entity 'FAIL' named entity 'PUUMALA HANTAVIRUS' named entity 'patients' named entity 'confirm' named entity 'fail' named entity 'puumala' named entity 'infection' named entity 'platelet' named entity 'SEVERITY' named entity 'HANTAVIRUS INFECTION' named entity 'PLATELET INDICES' covid:arg/4db442dee5f7675795f576b1f6b7be277decf03b named entity 'COHORT' named entity 'RELATION' named entity 'ACUTE' named entity 'CONFIRM' named entity 'CLINICAL' named entity 'THROMBOPOIETIN' named entity 'BUT' named entity 'ELEVATED' named entity 'THROMBOPOIESIS' named entity 'ACTIVE' named entity 'HANTAVIRUS' named entity 'VARIABLES' named entity 'PROCOAGULANT' named entity 'EVALUATED' named entity 'PREDICT' named entity 'CHANGES' named entity 'CLINICAL' named entity 'THROMBOCYTOPENIA' named entity 'DISEASE' named entity 'MECHANISMS' named entity 'PATIENTS' named entity 'relation' named entity 'hantavirus' named entity 'Elevated' named entity 'thrombopoiesis' named entity 'platelet' named entity 'hereditary spherocytosis' named entity 'platelet' named entity 'thrombin receptor' named entity 'infection' named entity 'vasculature' named entity 'endothelial cells' named entity 'platelet count' named entity 'fluid retention' named entity 'serum' named entity 'serum' named entity 'procoagulant' named entity 'acute phase' named entity 'infection' named entity 'platelet count' named entity 'procoagulant' named entity 'growth factor' named entity 'thrombopoiesis' named entity 'clinical diagnosis' named entity 'urinary output' named entity 'AKI' named entity 'low platelet count' named entity 'Tampere University Hospital' named entity 'Hemorrhage' named entity 'MPV' named entity 'kidney injury' named entity 'hematocrit' named entity 'Complete blood count' named entity 'D-dimer' named entity 'chronic obstructive pulmonary disease' named entity 'plasma' named entity 'platelets' named entity 'bleeding tendency' named entity 'nmol/L' named entity 'STAT' named entity 'coronavirus' named entity 'plasma' named entity 'serum'

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