About: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning

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About: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning
Creator	Hu, Han-Chung Kao, Kuo-Chin Wu, Chieh-Liang Tsai, Ming-Ju Chan, Ming-Cheng Chang, Ko-Wei Chen, Wei-Chih Chen, Yu-Mu Chien, Ying-Chun Chiu, Li-Chung Fang, Wen-Feng Liang, Shinn-Jye Peng, Chung-Kan Perng, Wann-Cherng Sheu, Chau-Chyun Wang, Hao-Chien Yang, Kuang-Yao
Source	PMC
abstract	BACKGROUND: Patients with influenza complicated with pneumonia are at high risk of rapid progression to acute respiratory distress syndrome (ARDS). Prone positioning with longer duration and lung-protective strategies might reduce the mortality level in ARDS. The aim of this study is to investigate the survival predictors of prone positioning in patients with ARDS caused by influenza pneumonia. METHODS: This retrospective study was conducted by eight tertiary referral centers in Taiwan. From January 1 to March 31 in 2016, all of the patients in intensive care units with virology-proven influenza pneumonia were collected, while all of those patients with ARDS and receiving prone positioning were enrolled. Demographic data, laboratory examinations, management records, ventilator settings and clinical outcomes were collected for analysis. RESULTS: During the study period, 336 patients with severe influenza pneumonia were screened and 263 patients met the diagnosis of ARDS. Totally, 65 patients receiving prone positioning were included for analysis. The 60-day survivors had lower Acute Physiology and Chronic Health Evaluation (APACHE) II score, pneumonia severity index (PSI), creatinine level and lower rate of receiving renal replacement therapy than non-survivors (22.4 ± 8.5 vs. 29.2 ± 7.4, p = 0.003; 106.6 ± 40.9 vs. 135.3 ± 48.6, p = 0.019; 1.2 ± 0.9 mg/dL vs. 3.1 ± 3.6 mg/dL, p = 0.040; and 4% vs. 42%, p < 0.005). Multivariate Cox regression analysis identified PSI (hazard ratio 1.020, 95% confidence interval 1.009–1.032; p < 0.001), renal replacement therapy (hazard ratio 6.248, 95% confidence interval 2.245–17.389; p < 0.001), and increase in dynamic driving pressure (hazard ratio 1.372, 95% confidence interval 1.095–1.718; p = 0.006) which were independent predictors associated with 60-day mortality. CONCLUSIONS: In the present study, in evaluating the effect of prone positioning in patients with influenza pneumonia-related ARDS, pneumonia severity index, renal replacement therapy and increase in dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13613-018-0440-4) contains supplementary material, which is available to authorized users.
has issue date	2018-09-24(xsd:dateTime)
bibo:doi	10.1186/s13613-018-0440-4
bibo:pmid	30251181
has license	cc-by
sha1sum (hex)	4dae1f8ae83eac32a8acf1a66481715afa398d05
schema:url	https://doi.org/10.1186/s13613-018-0440-4
resource representing a document's title	Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning
has PubMed Central identifier	PMC6153196
has PubMed identifier	30251181
schema:publication	Ann Intensive Care
resource representing a document's body	covid:4dae1f8ae83eac32a8acf1a66481715afa398d05#body_text
is schema:about of	named entity 'caused' named entity 'strategies' named entity 'patients' named entity 'survival' named entity 'severe' named entity 'MORTALITY' named entity 'RAPID PROGRESSION' named entity 'SURVIVAL' named entity 'REDUCE' named entity 'STUDY' named entity 'pneumonia' named entity 'investigate' named entity 'progression' named entity 'complicated' named entity 'acute respiratory distress syndrome' named entity 'pneumonia' named entity 'influenza' named entity 'Respiratory rate' named entity 'renal replacement therapy' named entity 'ECMO' named entity 'standard procedure' named entity 'influenza' named entity 'neuromuscular blocking agents' named entity 'pneumonia' named entity 'renal replacement therapy' named entity 'Cox regression' named entity '2009 pandemic' named entity 'ARDS' named entity 'ventilatory support' named entity 'viral culture' named entity 'influenza' named entity 'ARDS' named entity 'ICU' named entity 'renal replacement therapy' named entity 'PEEP' named entity 'Taiwan' named entity 'retrospective study' named entity 'pneumonia' named entity 'AKI' named entity 'Cox models' named entity 'randomized controlled trials' named entity 'mortality rate' named entity 'ARDS' named entity 'pneumonia' named entity 'H1N1' named entity 'refractory' named entity 'hazard ratio' named entity 'serologic test' named entity '95% confidence interval' named entity 'mm Hg' named entity 'tidal volume' named entity 'cardiac arrhythmia' named entity 'throat swab' named entity 'lung' named entity 'lung' named entity 'supine' named entity 'prone position' named entity 'retrospective study' named entity 'H3N2' named entity 'intensivist' named entity 'ARDS' named entity 'body weight' named entity 'pneumonia' named entity 'plateau pressure' named entity 'tidal volume'

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