About: Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19: A Systematic Review and Meta-Analysis

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About: Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19: A Systematic Review and Meta-Analysis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19: A Systematic Review and Meta-Analysis
Creator	Lakkireddy, Dhanunjaya Turagam, Mohit Patel, Siddharth Shah, Kuldeep Shah, Siddharth Velagapudi, Poonam Osman, Mohammed Fesc, Facc Garg, Jalaj Mph, Patel
Source	MedRxiv
abstract	Introduction. The 2019 novel Coronavirus (2019 nCoV), now declared a pandemic has an overall case fatality of 2 to 3% but it is as high as 50% in critically ill patients. D-dimer is an important prognostic tool, often elevated in patients with severe COVID-19 infection and in those who suffered death. In this systematic review, we aimed to investigate the prognostic role of D-dimer in COVID-19 infected patients. Methods. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting admission D-dimer levels in COVID-19 patients and its effect on mortality. Results. 18 studies (16 retrospective and 2 prospective) with a total of 3,682 patients met the inclusion criteria. The pooled mean difference (MD) suggested significantly elevated D-dimer levels in patients who died versus those survived (MD 6.13 mg/L, 95% CI 4.16 to 8.11, p <0.001). Similarly, the pooled mean D-dimer levels were significantly elevated in patients with severe COVID-19 infection (MD 0.54 mg/L, 95% CI 0.28 to 0.8, p< 0.001). In addition, the risk of mortality was four-fold higher in patients with positive D-dimer vs negative D-dimer (RR 4.11, 95% CI 2.48 to 6.84, p< 0.001) and the risk of developing the severe disease was two-fold higher in patients with positive D-dimer levels vs negative D-dimer (RR 2.04, 95% CI 1.34 to 3.11, p < 0.001). Conclusion. Our meta-analysis demonstrates that patients with COVID-19 presenting with elevated D-dimer levels have an increased risk of severe disease and mortality.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.29.20085407
has license	medrxiv
sha1sum (hex)	4d781bc3a167b207161c0fc6fdd8a510211d3b73
schema:url	https://doi.org/10.1101/2020.04.29.20085407
resource representing a document's title	Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19: A Systematic Review and Meta-Analysis
resource representing a document's body	covid:4d781bc3a167b207161c0fc6fdd8a510211d3b73#body_text
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