About: Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice

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About: Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice
Creator	Verthelyi, Daniela Manangeeswaran, Mohanraj Ireland, Derek
Source	PMC
abstract	The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain Barre and other neurological disorders as well as congenital defects that include microcephaly has created an urgent need to develop animal models to examine the pathogenesis of the disease and explore the efficacy of potential therapeutics and vaccines. Recently developed infection models for ZIKV utilize mice defective in interferon responses. In this study we establish and characterize a new model of peripheral ZIKV infection using immunocompetent neonatal C57BL/6 mice and compare its clinical progression, virus distribution, immune response, and neuropathology with that of C57BL/6-IFNAR KO mice. We show that while ZIKV infected IFNAR KO mice develop bilateral hind limb paralysis and die 5–6 days post-infection (dpi), immunocompetent B6 WT mice develop signs of neurological disease including unsteady gait, kinetic tremors, severe ataxia and seizures by 13 dpi that subside gradually over 2 weeks. Immunohistochemistry show viral antigen predominantly in cerebellum at the peak of the disease in both models. However, whereas IFNAR KO mice showed infiltration by neutrophils and macrophages and higher expression of IL-1, IL-6 and Cox2, B6 WT mice show a cellular infiltration in the CNS composed predominantly of T cells, particularly CD8+ T cells, and increased mRNA expression levels of IFNg, GzmB and Prf1 at peak of disease. Lastly, the CNS of B6 WT mice shows evidence of neurodegeneration predominantly in the cerebellum that are less prominent in mice lacking the IFN response possibly due to the difference in cellular infiltrates and rapid progression of the disease in that model. The development of the B6 WT model of ZIKV infection will provide insight into the immunopathology of the virus and facilitate assessments of possible therapeutics and vaccines.
has issue date	2016-11-17(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1006004
bibo:pmid	27855206
has license	cc0
sha1sum (hex)	4d5640c129096fd8a4da9d32030420def86285e5
schema:url	https://doi.org/10.1371/journal.ppat.1006004
resource representing a document's title	Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice
has PubMed Central identifier	PMC5113993
has PubMed identifier	27855206
schema:publication	PLoS Pathog
resource representing a document's body	covid:4d5640c129096fd8a4da9d32030420def86285e5#body_text
is schema:about of	named entity 'CNS' named entity 'CD8+ T cells' named entity 'neuropathology' named entity 'potential' named entity 'subside' named entity 'C57BL/6' named entity 'cellular' named entity 'mice' named entity 'infection' named entity 'responses' named entity 'infected' named entity 'expression' named entity 'mice' named entity 'Cox2' named entity 'paralysis' named entity 'Neurodegeneration' named entity 'ZIKV INFECTION' named entity 'ZIKA' named entity 'NEURODEGENERATION' named entity 'THE PEAK' named entity 'DISTRIBUTION' named entity 'SIGNS' named entity 'POSSIBLE' named entity 'NEURODEGENERATION' named entity 'MICROCEPHALY' named entity 'RESPONSE' named entity 'ASSOCIATED WITH' named entity 'TO EXAMINE' named entity 'HIND LIMB PARALYSIS' named entity 'KINETIC' named entity 'POTENTIAL' named entity 'CEREBELLUM' named entity 'VIRUS' named entity 'CNS' named entity 'DIFFERENCE' named entity '5-6 DAYS' named entity 'PATHOGENESIS' named entity 'RESPONSES' named entity 'C57BL' named entity 'LEVELS' named entity 'INTERFERON ' named entity 'RECENT' named entity 'INCLUDING' named entity 'PERIPHERAL' named entity 'DPI' named entity 'NEUTROPHILS' named entity 'PEAK' named entity 'DEFECTIVE' named entity 'ATAXIA' named entity 'IMMUNE RESPONSE' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'MICE' named entity 'INFECTION' named entity 'CELL INFILTRATION ' named entity '2 WEEKS' named entity 'MODEL OF' named entity 'EVIDENCE OF' named entity 'OTHER NEUROLOGICAL DISORDERS' named entity 'THERAPEUTICS' named entity 'IMMUNOCOMPETENT' named entity 'T CELL' named entity 'ZIKA VIRUS' named entity 'DEVELOPMENT' named entity 'COMPARE' named entity 'MODEL' named entity 'STUDY' named entity 'NEUROPATHOLOGY' named entity 'VACCINES' named entity 'BARRE' named entity 'USING' named entity 'MODELS' named entity 'MACROPHAGES' named entity 'IL-6' named entity 'POST' named entity 'TREMORS' named entity 'MRNA EXPRESSION' named entity 'CD8' named entity 'INCLUDE' named entity 'NEW'

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