About: Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response

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About: Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response
Creator	Zheng, Ming Reading, Patrick Alcorn, John Bedford, James Wakim, Linda Short, Bennett-Wood, Vicki Dagley, Laura Infusini, Giuseppe Kirsty, Renfree Villalon-Letelier, Fernando
Source	Medline; PMC
abstract	Exosomes are extracellular vesicles secreted by cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighboring or distant cells. While a role for exosomes in antimicrobial defense has recently emerged, currently very little is known regarding the nature and functional relevance of exosomes generated in vivo, particularly during an active viral infection. Here, we characterized exosomes released into the airways during influenza virus infection. We show that these vesicles dynamically change in protein composition over the course of infection, increasing expression of host proteins with known anti-influenza activity, and viral proteins with the potential to trigger host immune responses. We show that exosomes released into the airways during influenza virus infection trigger pulmonary inflammation and carry viral antigen that can be utilized by antigen presenting cells to drive the induction of a cellular immune response. Moreover, we show that attachment factors for influenza virus, namely α2,3 and α2,6-linked sialic acids, are present on the surface of airway exosomes and these vesicles have the ability to neutralize influenza virus, thereby preventing the virus from binding and entering target cells. These data reveal a novel role for airway exosomes in the antiviral innate immune defense against influenza virus infection.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.00887
bibo:pmid	32477358
has license	cc-by
sha1sum (hex)	4d124b37e288a897cd92c9513f7f6915858b1d0b
schema:url	https://doi.org/10.3389/fimmu.2020.00887
resource representing a document's title	Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response
has PubMed Central identifier	PMC7236881
has PubMed identifier	32477358
schema:publication	Front Immunol
resource representing a document's body	covid:4d124b37e288a897cd92c9513f7f6915858b1d0b#body_text
is schema:about of	named entity 'cellular immune response' named entity 'influenza' named entity 'influenza' named entity 'infection' named entity 'drive' named entity 'exosomes' named entity 'induction' named entity 'antiviral' named entity 'exosomes' named entity 'lipids' named entity 'intercellular communication' named entity 'exosomes' named entity 'released' named entity 'influenza' named entity 'viral infection' named entity 'emerged' named entity 'reveal' named entity 'vesicles' named entity 'Serve' named entity 'host immune responses' named entity 'influenza virus' named entity 'extracellular vesicles' named entity 'biologically active' named entity 'target cells' named entity 'viral infection' named entity 'Exosomes' named entity 'RNAs' named entity 'Antiviral' named entity 'virus' named entity 'exosomes' named entity 'exosome' named entity 'Qiagen' named entity 'exosomes' named entity 'coronaviruses' named entity 'decoy targets' named entity 'exosomes' named entity 'CD4 +' named entity 'influenza virus' named entity 'mice' named entity 'methionine' named entity 'anesthetized' named entity 'CD9' named entity '2A-C' named entity 'mice' named entity 'exosomes' named entity 'wild-type' named entity 'anti-influenza' named entity 'Norway' named entity 'reverse genetics' named entity 'sialylated' named entity 'dH 2' named entity 'pathological conditions' named entity 'exosome' named entity 'exosomes' named entity 'MCP-1' named entity 'exosomes' named entity 'viruses' named entity 'flow cytometry' named entity 'acetone' named entity 'exosomes' named entity 'CD8 +' named entity 'CD9' named entity 'influenza virus' named entity '250 mM' named entity 'anti-influenza' named entity 'ppm' named entity 'staining' named entity 'exosome' named entity 'tracheas' named entity 'influenza virus' named entity 'exosomes'

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