About: MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells

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About: MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells
Creator	Chakrabarti, J Ghosh, Z Mallick, B
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS), caused by the coronavirus SARS-CoV, is an acute infectious disease with significant mortality. A typical clinical feature associated with SARS is pulmonary fibrosis and associated lung failure. In the aftermath of the SARS epidemic, although significant progress towards understanding the underlying molecular mechanism of the infection has been made, a large gap still remains in our knowledge regarding how SARS-CoV interacts with the host cell at the onset of infection. The rapidly changing viral genome adds another variable to this equation. We have focused on a novel concept of microRNA (miRNA)–mediated host–virus interactions in bronchoalveolar stem cells (BASCs) at the onset of infection by correlating the “BASC–microRNome” with their targets within BASCs and viral genome. This work encompasses miRNA array data analysis, target prediction, and miRNA–mRNA enrichment analysis and develops a complex interaction map among disease-related factors, miRNAs, and BASCs in SARS pathway, which will provide some clues for diagnostic markers to view an overall interplay leading to disease progression. Our observation reveals the BASCs (Sca-1+ CD34+ CD45- Pecam-), a subset of Oct-4+ ACE2+ epithelial colony cells at the broncho-alveolar duct junction, to be the prime target cells of SARS-CoV infection. Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination until successful transmission takes place. Viral Nucleocapsid and Spike protein targets seem to co-opt downregulated miR-223 and miR-98 respectively within BASCs to control the various stages of BASC differentiation, activation of inflammatory chemokines, and downregulation of ACE2. All these effectively accounts for a successful viral transmission and replication within BASCs causing continued deterioration of lung tissues and apparent loss of capacity for lung repair. Overall, this investigation reveals another mode of exploitation of cellular miRNA machinery by virus to their own advantage.
has issue date	2009-11-13(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0007837
bibo:pmid	19915717
has license	cc-by
sha1sum (hex)	4d0d82be6ba94422e252ff243a2cd89d13ea736a
schema:url	https://doi.org/10.1371/journal.pone.0007837
resource representing a document's title	MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells
has PubMed Central identifier	PMC2773932
has PubMed identifier	19915717
schema:publication	PLoS One
resource representing a document's body	covid:4d0d82be6ba94422e252ff243a2cd89d13ea736a#body_text
is schema:about of	named entity 'MOLECULAR BASIS' covid:arg/4d0d82be6ba94422e252ff243a2cd89d13ea736a named entity 'ENRICHMENT ANALYSIS' named entity 'MEDIATED' named entity 'MIRNA' named entity 'COMPLEX' named entity 'REPLICATION' named entity 'STEM CELLS' named entity 'ONSET OF' named entity 'CAUSING' named entity 'PROGRESS' named entity 'INTERACTION' named entity 'STAGES' named entity 'UNDERSTANDING' named entity 'VIRAL GENOME' named entity 'THEIR' named entity 'SARS' named entity 'PATHWAY' named entity 'LEADING' named entity 'ACE2' named entity 'WORK' named entity 'NOVEL' named entity 'PLACE' named entity 'MIRNA ARRAY' named entity 'CAPACITY' named entity 'MIR-98' named entity 'STEM CELLS' named entity 'REVEALS' named entity 'LUNG' named entity 'OPT' named entity 'HAVE' named entity 'OVERALL' named entity 'ITS' named entity 'CD34' named entity 'HOST' named entity 'MRNA' named entity 'EQUATION' named entity 'RELATED' named entity 'EPITHELIAL' named entity 'MICRORNA' named entity 'INFECTION' named entity 'SIGNIFICANT' named entity 'VIEW' named entity 'CONCEPT' named entity 'FOCUSED' named entity 'TRANSMISSION' named entity 'INFLAMMATORY' named entity 'DIFFERENTIATION' named entity 'CONTINUED' named entity 'IMMUNE ELIMINATION' named entity 'JUNCTION' named entity 'CELLS' named entity 'CELLULAR' named entity 'SUBSET' named entity 'UPREGULATED' named entity 'MORTALITY' named entity 'THESE' named entity 'HOW' named entity 'EPIDEMIC' named entity 'TARGETS' named entity 'MAP' named entity 'SARS-COV' named entity 'COLONY' named entity '574' named entity 'DEVELOPS' named entity 'TYPICAL' named entity 'ADVANTAGE' named entity 'ALVEOLAR DUCT' named entity 'VIRAL TRANSMISSION' named entity 'DETERIORATION' named entity 'MODE' named entity 'VARIABLE' named entity 'DISEASE' named entity 'MIRNAS' named entity 'LUNG REPAIR' named entity 'PROVIDE' named entity 'ACTIVATION' named entity 'ANALYSIS' named entity 'SARS'

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