About: A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
Creator	Dittmann, Meike Hoffmann, Hans-Heinrich Bieniasz, Paul Correspondence, Charles
Source	Elsevier; Medline; PMC
abstract	Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene SERPINE1, encoding plasminogen activator inhibitor 1 (PAI-1). By targeting extracellular airway proteases, PAI-1 inhibits IAV glycoprotein cleavage, thereby reducing infectivity of progeny viruses. This was biologically relevant for IAV restriction in vivo. Further, partial PAI-1 deficiency, attributable to a polymorphism in human SERPINE1, conferred increased susceptibility to IAV in vitro. Together, our findings reveal that manipulating the extracellular environment to inhibit the last step in a virus life cycle is an important mechanism of the antiviral response.
has issue date	2015-02-12(xsd:dateTime)
bibo:doi	10.1016/j.cell.2015.01.040
bibo:pmid	25679759
has license	cc-by
sha1sum (hex)	4d0c8c015ad0e4fd92840318238c4ef4a36fdb81
schema:url	https://doi.org/10.1016/j.cell.2015.01.040
resource representing a document's title	A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
has PubMed Central identifier	PMC4328142
has PubMed identifier	25679759
schema:publication	Cell
resource representing a document's body	covid:4d0c8c015ad0e4fd92840318238c4ef4a36fdb81#body_text
is schema:about of	named entity 'cleavage' named entity 'Recent' named entity 'acting' named entity 'Influenza A' covid:arg/4d0c8c015ad0e4fd92840318238c4ef4a36fdb81 named entity 'human' named entity 'intracellular' named entity 'viruses' named entity 'light' named entity 'influenza A virus' named entity 'intracellular' named entity 'ISG' named entity 'murine' named entity 'IAV' named entity 'extracellular' named entity 'IAV' named entity 'apoptosis' named entity 'plasminogen' named entity 'mice' named entity 'SERPIN' named entity 'protein' named entity 'A549' named entity 'protease inhibitors' named entity 'PAI-1' named entity 'VSV' named entity 'GFP' named entity 'GFP' named entity 'proteases' named entity 'endogenous' named entity 'PAI-1' named entity 'IAV' named entity 'ISGs' named entity 'transmembrane' named entity 'titration' named entity 'fibroblast' named entity 'lungs' named entity 'glycoprotein' named entity 'arginine' named entity 'fibrinolysis' named entity 'subtilisin' named entity 'ISGs' named entity 'Plaque assays' named entity 'IAV' named entity 'PAI-1' named entity 'A549' named entity 'furin' named entity 'infectivity' named entity 'Serpine1' named entity 'club cell secretory protein' named entity 'IAV' named entity 'Host Factor' named entity 'IAV' named entity 'qRT-PCR' named entity 'Weight loss' named entity 'IAV' named entity 'hpi' named entity 'life cycles' named entity 'transfected' named entity 'TNFSF10' named entity 'kinetics' named entity 'epithelial' named entity 'negative control' named entity 'neuraminidase inhibitors' named entity 'hpi' named entity 'furin' named entity 'a-HA' named entity 'extracellular' named entity 'qRT-PCR' named entity 'glycoprotein' named entity 'TGF-b' named entity 'PAI-1' named entity 'antiviral' named entity 'PAI-1' named entity 'host defense' named entity 'innate immune' named entity 'Plasminogen activator inhibitor' named entity 'protease' named entity 'IAV'

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