About: Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

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About: Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions
Creator	Ali, Muhammad Fatima, Kaneez Ali, \| Khan, Tariq Raza, Abida Ullah, Ikram Ali, Ain Khalil, Talha Muhammad Idrees, \| Ovais, \| Qurat, \| Shinwari, Khan Tariq Khan, \| Zabta, \|
Source	PMC
abstract	Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach. & Thonn., Salvia miltiorrhiza Bunge., Astragalus membranaceus (Fisch.) Bunge, Capparis spinosa (L.), Cichorium intybus (L.), Solanum nigrum (L.), Sapindus mukorossi Gaertn., Ginkgo biloba (L.), Woodfordia fruticosa (L.) Kurz, Vitex trifolia (L.), Schisandra chinensis (Turcz.) Baill., Cuscuta chinensis (Lam.), Lycium barbarum, Angelica sinensis (Oliv.) Diels, and Litsea coreana (H. Lev.). The probable modes of action of these plants include immunomodulation, stimulation of hepatic DNA synthesis, simulation of superoxide dismutase and glutathione reductase to inhibit oxidation in hepatocytes, reduction of intracellular reactive oxygen species by enhancing levels of antioxidants, suppression of ethanol‐induced lipid accumulation, inhibition of nucleic acid polymerases to downregulate viral mRNA transcription and translation, free radical scavenging and reduction of hepatic fibrosis by decreasing the levels of transforming growth factor beta‐1, and collagen synthesis in hepatic cells. However, further research is needed to identify, characterize, and standardize the active ingredients, useful compounds, and their preparations for the treatment of liver diseases.
has issue date	2017-10-19(xsd:dateTime)
bibo:doi	10.1002/ptr.5957
bibo:pmid	29047177
has license	no-cc
sha1sum (hex)	4cc3eb46411a9cef0a5669147ecd473edb192319
schema:url	https://doi.org/10.1002/ptr.5957
resource representing a document's title	Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions
has PubMed Central identifier	PMC7167792
has PubMed identifier	29047177
schema:publication	Phytother Res
resource representing a document's body	covid:4cc3eb46411a9cef0a5669147ecd473edb192319#body_text
is schema:about of	named entity 'OXIDATION' named entity 'REACTIVE OXYGEN SPECIES' named entity 'CONVENTIONAL' named entity 'INCLUDE' named entity 'SUPPRESSION' named entity 'SIMULATION' named entity 'hepatic' named entity 'transforming growth factor beta' named entity 'Cuscuta chinensis' named entity 'herbal medicine' named entity 'glutathione reductase' named entity 'Phyllanthus' named entity 'Litsea' named entity 'Astragalus membranaceus' named entity 'Sapindus mukorossi' named entity 'ethanol' named entity 'hepatoprotective' named entity 'animal models' named entity 'free radicals' named entity 'cirrhosis' named entity 'liver cell' named entity 'pesticides' named entity 'hepatoprotective' named entity 'liver' named entity 'liver' named entity 'glycyrrhizin' named entity 'glucose-6-phosphate' named entity 'intraperitoneal injection' named entity 'glutathione peroxidase' named entity 'pyridine' named entity 'herbals' named entity 'catalase' named entity 'glycoside' named entity 'CYP1A1' named entity 'Silymarin' named entity 'chronic liver' named entity 'liver diseases' named entity 'bioactive compounds' named entity 'medicinal plant' named entity 'oxidative stress' named entity 'hepatotoxicity' named entity 'hepatoprotective' named entity 'herbal medicines' named entity 'liver diseases' named entity 'SGOT' named entity 'Thailand' named entity 'polysaccharides' named entity 'herbal products' named entity 'transgenic mice' named entity 'lipid peroxidation' named entity 'herbal treatment' named entity 'HBsAg' named entity 'hepatoprotective' named entity 'silymarin' named entity 'secretion' named entity 'liver fibrosis' named entity 'thiols' named entity 'thioacetamide' named entity 'lipopolysaccharide' named entity 'liver' named entity 'viruses' named entity 'petroleum ether' named entity 'glutathione reductase' named entity 'Quercetin' named entity 'liver' named entity 'herbals' named entity 'traditional Chinese medicinal' named entity 'hepatic injury'

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