About: Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains

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About: Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains
Creator	Zhang, J Gimenez-Lirola, L Piñeyro, P Sinha, A Temeeyasen, G
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV) strains can be divided into non-S-INDEL and S-INDEL strains. PEDV pathogenesis is strain-specific, and studies in neonatal pigs have demonstrated that the PEDV non-S-INDEL strains are more pathogenic than the PEDV S-INDEL strains. RNA viruses, including PEDV, can interact with a large number of pattern recognition receptors (PRRs) in the intestinal mucosa, including toll-like receptors (TLRs) and RIG-I-like receptors (RLRs). We investigated the differential gene modulation of TLRs, RIG-I, and downstream mediators on the intestinal mucosa of neonatal pigs infected with PEDV S-INDEL and non-S-INDEL strains. Ten five-day-old piglets were inoculated orally with 10ml of 104 TCDI50/ml of either PEDV non-S-INDEL or S-INDEL strains. PEDV S-INDEL infection induced pro-inflammatory cytokines through the non-canonical NF-κB signaling pathway by activating RIG-I. In contrast, PEDV non-S-INDEL infection suppressed the induction of pro-inflammatory cytokines and type 1 interferon production by down-regulation of TLRs and downstream signaling molecules.
has issue date	2018-04-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.11.024
bibo:pmid	29249266
has license	els-covid
sha1sum (hex)	4cb911d04112bf712c8a79d7812909d26d330c0c
schema:url	https://doi.org/10.1016/j.virol.2017.11.024
resource representing a document's title	Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains
has PubMed Central identifier	PMC7112111
has PubMed identifier	29249266
schema:publication	Virology
resource representing a document's body	covid:4cb911d04112bf712c8a79d7812909d26d330c0c#body_text
is schema:about of	named entity 'INTESTINAL MUCOSA' named entity 'INDEL' named entity 'MEDIATORS' named entity 'DIFFERENTIAL' named entity 'LIKE' named entity 'DOWNSTREAM' named entity 'TLR' named entity 'MODULATION' named entity 'RECEPTOR' named entity 'NON' named entity 'RECOGNITION' named entity 'RIG-I' named entity 'GENE' named entity 'STRAINS' named entity 'PATTERN' named entity 'PIGS' named entity 'INFECTED' named entity 'PEDV' named entity 'intestinal mucosa' named entity 'pigs' named entity 'gene' named entity 'TLR' named entity 'immune modulation' named entity 'treatment groups' named entity 'TRAF6' named entity 'pro-inflammatory cytokines' named entity 'IFN-α' named entity 'gene' named entity 'NF-kB' named entity 'PEDV' named entity 'PEDV' named entity 'gene' named entity 'Primer' named entity 'infectious bronchitis virus' named entity 'macrophages' named entity 'IL-12' named entity 'RIG-I' named entity 'gene expression' named entity 'Devaraj' named entity 'PEDV' named entity 'TIR' named entity 'PEDV' named entity 'RNA' named entity 'pig' named entity 'dimer' named entity 'RelA' named entity 'TLR4' named entity 'pro-inflammatory cytokines' named entity 'type 1 interferon' named entity 'RIG-I' named entity 'innate immune response' named entity '0.01' named entity 'Kalamazoo' named entity 'gene expression' named entity 'infection' named entity 'infection' named entity 'Pathogen' named entity 'TLR' named entity 'NF-kB' named entity 'PEDV' named entity 'intracytoplasmic' named entity 'nidoviruses' named entity 'TLR3' named entity 'gene' named entity 'gene' named entity 'interleukin' named entity 'TLR3' named entity 'NF-κB' named entity 'TLRs' named entity 'GAPDH' named entity 'TLRs' named entity 'Nuclear factor' named entity 'PEDV' named entity 'canonical pathway' named entity 'intestinal mucosa' named entity 'IRF3' named entity 'NF-kB'

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