About: Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism
Creator	Zhang, Yan Li, Yue Zhang, Li, Wen-Xiong Wang, Yong-Jun Wong, Man-Sau Zhang, Jia-Li
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: : Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. PURPOSE: : This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. METHODS: : Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. RESULTS: : The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. CONCLUSION: : TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.1016/j.phymed.2020.153297
bibo:pmid	32798019
has license	no-cc
sha1sum (hex)	4c7839bd416ab1e4ee9b412856f057f1176fb008
schema:url	https://doi.org/10.1016/j.phymed.2020.153297
resource representing a document's title	Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism
has PubMed Central identifier	PMC7405862
has PubMed identifier	32798019
schema:publication	Phytomedicine
resource representing a document's body	covid:4c7839bd416ab1e4ee9b412856f057f1176fb008#body_text
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