About: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures

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About: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
Creator	Molina, Carlos Lam, Matthew Maniruzzaman, Mohammed Nokhodchi, Ali
source	PMC
abstract	This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2–10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research.
has issue date	2016-08-10(xsd:dateTime)
bibo:doi	10.1208/s12249-016-0596-x
bibo:pmid	27511111
has license	cc-by
sha1sum (hex)	4c42093bf6e8888afed68488a0b8e99fbb71b8d0
schema:url	https://doi.org/10.1208/s12249-016-0596-x
resource representing a document's title	Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
has PubMed Central identifier	PMC6974489
has PubMed identifier	27511111
schema:publication	AAPS PharmSciTech
resource representing a document's body	covid:4c42093bf6e8888afed68488a0b8e99fbb71b8d0#body_text
is schema:about of	named entity 'monoclinic' named entity 'assess' named entity 'modulated' named entity 'monoclinic' named entity 'binary' named entity 'polymorphic transformations' named entity 'monoclinic' named entity 'micro' named entity 'conducted' named entity 'METHACRYLATE' named entity 'COPOVIDONE' named entity 'CONTROLLED' named entity 'REGARDLESS' named entity 'polymeric' named entity 'The' named entity 'application' named entity 'monitor' named entity 'The' named entity 'blends' named entity '2-pyrrolidone' named entity 'single' named entity 'study' named entity 'microns' named entity 'altered' named entity 'concentrations' named entity 'binary' named entity 'crystalline' named entity 'Hydrophilic' named entity 'carriers' named entity 'Study' named entity 'SEM' named entity 'vinyl acetate' named entity 'polymorphic form' named entity 'PMOL' named entity 'X-ray crystallography' named entity 'amorphous' named entity 'physical properties' named entity 'monoclinic form' named entity 'microscopy' named entity 'scanning electron microscopy' named entity 'orthorhombic' named entity 'monoclinic form' named entity 'morphology' named entity 'solid state' named entity 'Acetaminophen' named entity 'Polymorphs' named entity 'Polymer' named entity 'mixtures' named entity 'precipitation' named entity 'temperature effects' named entity 'PMOL' named entity 'bio-sensing' named entity 'relaxation time' named entity 'crystallisation' named entity 'pharmaceutical' named entity 'enthalpy' named entity 'polymers' named entity 'DSC' named entity 'crystallization' named entity 'amorphous' named entity 'analgesic' named entity 'polymorphic form' named entity 'polymers' named entity 'miscibility' named entity 'Germany' named entity 'crystal structure' named entity 'DSC' named entity 'single crystal' named entity 'EPO' named entity 'Germany' named entity 'Creative Commons license' named entity 'n-hexane' named entity 'ultrasound' named entity 'mechanical properties' named entity 'monoclinic form' named entity 'dosage forms' named entity 'polymer' named entity 'crystallinity'

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