About: An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.

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About: An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
Creator	Sicard, Antoine Caillard, Sophie Kamar, Nassim Anglicheau, Dany Bamoulid, Jamal Bertrand, Dominique Blancho, Gilles Bouvier, Nicolas Chavarot, Nathalie Chemouny, Jonathan Colosio, Charlotte Couzi, Lionel Durrbach, Antoine Duveau, Agnes Frimat, Luc Gatault, Philippe Greze, Clarisse Grimbert, Philippe Hazzan, Marc Le Meur, Yannick Legris, Tristan Masset, Christophe Matignon, Marie Moal, Valerie Moulin, Bruno Snanoudj, Renaud Thaunat, Olivier Westeel, Pierre
Source	Elsevier; Medline; PMC
abstract	Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1016/j.kint.2020.08.005
bibo:pmid	32853631
has license	no-cc
sha1sum (hex)	4bfb279fca0855d2a1f588d1b09f7b62b7ba9b66
schema:url	https://doi.org/10.1016/j.kint.2020.08.005
resource representing a document's title	An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
has PubMed Central identifier	PMC7444636
has PubMed identifier	32853631
schema:publication	Kidney Int
resource representing a document's body	covid:4bfb279fca0855d2a1f588d1b09f7b62b7ba9b66#body_text
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