About: The Dual Role of TNF in Pulmonary Edema

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Dual Role of TNF in Pulmonary Edema
Creator	Chakraborty, Trinad Lucas, Rudolf Yang, Guang White, Richard Gorshkov, Boris Hamacher, Jürg Sridhar, Supriya Verin, Alexander
Source	Elsevier; Medline; PMC
abstract	—Pulmonary edema, a major manifestation of left ventricular heart failure, renal insufficiency, shock, diffuse alveolar damage and lung hypersensitivity states, is a significant medical problem worldwide and can be life-threatening. The proinflammatory cytokine tumor necrosis factor (TNF) has been shown to contribute to the pathogenesis and development of pulmonary edema. However, some recent studies have demonstrated surprisingly that TNF can also promote alveolar fluid reabsorption in vivo and in vitro. This protective effect of the cytokine is mediated by the lectin-like domain of the cytokine, which is spatially distinct from the TNF receptor binding sites. The TIP peptide, a synthetic mimic of the lectin-like domain of TNF, can significantly increase alveolar fluid clearance and improve lung compliance in pulmonary edema models. In this review, we will discuss the dual role of TNF in pulmonary edema. ABBREVIATIONS: —tumor necrosis factor (TNF); acute lung injury (ALI); acute respiratory distress syndrome (ARDS); positive end-expiratory pressure (PEEP);epithelial sodium channel (ENaC);neural precursor cell-expressed developmentally downregulated (gene 4) protein (Nedd4-2);serum and glucocorticoid dependent kinase (Sgk-1);insulin-like growth factor 1 (IGF-1);Protein Kinase C (PKC);reactive oxygen species (ROS);myosin light chain (MLC);pneumolysin (PLY);listeriolysin (LLO);interleukin (IL);bronchoalveolar lavage fluids (BALF);Bacillus Calmette-Guerin (BCG);TNF receptor type 1 (TNFR1); TNF receptor type 2 (TNF-R2);
has issue date	2010-01-01(xsd:dateTime)
bibo:doi	10.4103/0975-3583.59983
bibo:pmid	21188088
has license	cc-by
sha1sum (hex)	4bf4126bc494f791347e285c91b25bc2814beb4d
schema:url	https://doi.org/10.4103/0975-3583.59983
resource representing a document's title	The Dual Role of TNF in Pulmonary Edema
has PubMed Central identifier	PMC3004168
has PubMed identifier	21188088
schema:publication	J Cardiovasc Dis Res
resource representing a document's body	covid:4bf4126bc494f791347e285c91b25bc2814beb4d#body_text
is schema:about of	named entity 'STUDIES' named entity 'REABSORPTION' named entity 'OXYGEN' named entity 'PROMOTE' named entity 'SIGNIFICANT' named entity 'TYPE 1' named entity 'SHOCK' named entity 'HYPERSENSITIVITY' named entity 'GROWTH FACTOR' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'IS A' named entity 'ABBREVIATIONS' named entity 'VENTRICULAR' named entity 'CYTOKINE' named entity 'KINASE' named entity 'LAVAGE' named entity 'ACUTE LUNG INJURY' named entity 'FLUIDS' named entity 'POSITIVE END-EXPIRATORY PRESSURE' named entity 'SODIUM CHANNEL' named entity 'ALI' named entity 'major' named entity 'problem' named entity 'ENaC' named entity 'reactive oxygen species (ROS)' named entity 'sodium channel' named entity 'bronchoalveolar lavage' named entity 'pulmonary edema' named entity 'domain' named entity 'domain' named entity 'ROLE' named entity 'PULMONARY EDEMA' named entity 'HAVE' named entity 'LUNG COMPLIANCE' named entity 'PRECURSOR CELL' named entity 'PATHOGENESIS' named entity 'WORLDWIDE' named entity 'BINDING SITES' named entity 'TNF RECEPTOR' named entity 'MEDICAL PROBLEM' named entity 'REVIEW' named entity 'DUAL' named entity 'RECENT' named entity 'TYPE 2' named entity 'CONTRIBUTE ' named entity 'MODELS' named entity 'MANIFESTATION OF' named entity 'DEPENDENT' named entity 'DEMONSTRATED' named entity 'RESEARCH' named entity 'TNF' named entity 'ACCESS' named entity 'REVIEW' named entity 'JOURNAL ' named entity 'INCREASE' named entity 'ROLE' named entity 'HEART FAILURE' named entity 'DISTINCT FROM' named entity 'TNF RECEPTOR BINDING' named entity 'ALVEOLAR FLUID' named entity 'LUNG' named entity 'DOMAIN' named entity 'SYNTHETIC' named entity 'PROINFLAMMATORY CYTOKINE' named entity 'TUMOR NECROSIS FACTOR ' named entity 'GLUCOCORTICOID' named entity 'CYTOKINE ' named entity 'PROTEIN ' named entity 'DEVELOPMENT' named entity 'RECEPTOR TYPE' named entity 'MEDIATED' named entity 'DISCUSS' named entity 'DUAL' named entity 'OPEN'

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