About: Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
Creator	Balaguer-Roselló, Aitana Montoro, Juan Sanz, Guillermo Lorenzo, Ignacio Sanz, Miguel Luis Piñana, José Guerreiro, • Gómez, Dolores María, • Sanz, • Aguado, Cristina González Barberá, Eva Salavert, • Tofán, Luiza
Source	Medline; PMC
abstract	Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infections were diagnosed in 62 (29%) patients. Upper respiratory tract disease (URTD) occurred in 61 (54%) whereas lower respiratory tract disease (LRTD) in 53 (46%). The 5-year cumulative incidence of CARV infection was 29%. RFs for developing CARV infections were: prednisone-based graft-versus-host disease (GVHD) prophylaxis and grade II–IV acute GVHD. RFs analysis of CARV progression to LRTD identified 2007–2009 period and absolute lymphocyte count (ALC) < 0.5 × 10(9)/L. ALC < 0.5 × 10(9)/L had a negative impact on day 60 mortality in both overall CARV and those with LRTD, whereas proven LRTD was associated with higher day 60 mortality. CARV infections had a negative effect on non-relapse mortality. Overall survival at day 60 after CARV detection was significantly lower in recipients with LRTD compared with URTD (74% vs. 93%, respectively). In conclusion, CARV infections after UCBT are frequent and may have a negative effect in the outcomes, in particular in the context of lymphocytopenia.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1038/s41409-020-0943-0
bibo:pmid	32415227
has license	no-cc
sha1sum (hex)	4be5bc2ad73cdc70a46a0e84d4dbf920fe79f191
schema:url	https://doi.org/10.1038/s41409-020-0943-0
resource representing a document's title	Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
has PubMed Central identifier	PMC7227453
has PubMed identifier	32415227
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:4be5bc2ad73cdc70a46a0e84d4dbf920fe79f191#body_text
is schema:about of	named entity 'prophylaxis' named entity 'Upper respiratory tract disease' named entity 'risk factors' named entity 'GVHD' named entity 'UCBT' named entity 'URTD' named entity 'prednisone' named entity 'virus infections' named entity 'umbilical cord blood transplantation' named entity 'aerosolized' named entity 'UCBT' named entity 'UCBT' named entity 'epidemiology' named entity 'relapse' named entity 'septic shock' named entity 'infectious disease' named entity 'RFs' named entity 'UCBT' named entity 'prednisone' named entity 'influenza virus' named entity 'infection' named entity 'morbidity' named entity 'influenza vaccination' named entity 'prophylaxis' named entity 'cyclosporine' named entity 'UCBT' named entity 'corticosteroids' named entity 'prophylaxis' named entity 'respiratory failure' named entity 'cumulative incidence' named entity 'risk factor' named entity 'vaccination' named entity 'multivariate analyses' named entity 'GVHD' named entity 'HCoV HKU1' named entity 'respiratory symptoms' named entity '2.2' named entity 'Helsinki' named entity 'microbiological' named entity 'epidemiological data' named entity 'RFs' named entity 'busulfan' named entity 'HPiV' named entity 'HPiV' named entity 'stem cell' named entity 'covariate' named entity 'HPiV' named entity 'first-line' named entity 'UCBT' named entity 'lymphopenia' named entity 'infection' named entity 'RT-PCR' named entity 'lymphopenia' named entity 'HSCT' named entity 'infusion' named entity 'UCBT' named entity 'RSV' named entity 'RFs' named entity 'influenza A virus' named entity 'pathogens' named entity 'stem cell' named entity 'infection' named entity 'antigen' named entity 'infection' named entity 'Kaplan-Meier curves' named entity 'HSCT' named entity 'OC43' named entity 'cyclosporine'

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