About: Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID‐19/SARS‐CoV‐2

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About: Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID‐19/SARS‐CoV‐2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID‐19/SARS‐CoV‐2
Creator	Gao, Jie Li, Hua Chen, \| Ma, Lu Ma, \| Wu, Duojiao Li, Yunjin Xu, Qiyue
topic	covid:4bb64af6cb2ed16bf0c6e7c35cc990b21c145810#this
Source	Medline; PMC
abstract	Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) disease (COVID‐19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS‐CoV‐2, could indicate the susceptibility to SARS‐CoV‐2 infection, here we systematically dissected ACE2 expression using large‐scale multi‐omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS‐CoV‐2 infection for certain tissues. Strikingly, ACE2 was up‐regulated in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, oesophageal carcinoma, kidney renal papillary cell carcinoma, lung adenocarcinoma and uterine corpus endometrial carcinoma compared to controls. Furthermore, the patients with common chronic diseases regarding angiocardiopathy, type 2 diabetes, liver, pneumonia and hypertension were also with higher ACE2 expression compared to related controls, which were validated using independent data sets. Collectively, our study may reveal a novel important mechanism that the patients with certain cancers and chronic diseases may express higher ACE2 expression compared to the individuals without diseases, which could lead to their higher susceptibility to multi‐organ injury of SARS‐CoV‐2 infection.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.1111/jcmm.15607
bibo:pmid	32639084
has license	cc-by
sha1sum (hex)	4bb64af6cb2ed16bf0c6e7c35cc990b21c145810
schema:url	https://doi.org/10.1111/jcmm.15607
resource representing a document's title	Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID‐19/SARS‐CoV‐2
has PubMed Central identifier	PMC7361264
has PubMed identifier	32639084
schema:publication	J Cell Mol Med
resource representing a document's body	covid:4bb64af6cb2ed16bf0c6e7c35cc990b21c145810#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/4bb64af6cb2ed16bf0c6e7c35cc990b21c145810
is schema:about of	named entity 'oesophageal' named entity 'express' named entity 'Since' named entity 'ACE2' named entity 'reveal' named entity 'pathological' named entity 'profiling' named entity 'expression' named entity 'DISEASES FACE' named entity 'UTERINE CORPUS ENDOMETRIAL CARCINOMA' named entity 'TYPE 2 DIABETES' named entity 'SARS-COV-2 INFECTION' named entity 'INDEPENDENT' named entity 'adenocarcinoma' named entity 'compared' named entity 'adenocarcinoma' named entity 'chronic diseases' named entity 'cell' named entity 'lung adenocarcinoma' named entity 'patients' named entity 'expression' named entity 'papillary' named entity 'ACE2' named entity 'carcinoma' named entity 'uterine' named entity 'cervical' named entity 'validated' named entity 'cancers' named entity 'multi-omics' named entity 'ACE2' named entity 'infection' named entity 'hypertension' named entity 'receptor' named entity 'uterine corpus endometrial carcinoma' named entity 'lung adenocarcinoma' named entity 'infection' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'chronic diseases' named entity 'ACE2' named entity 'endocervical' named entity 'chronic diseases' named entity 'ACE2' named entity 'ACE2' named entity 'regulatory networks' named entity 'methylation' named entity 'Genotype' named entity 'transcription factor' named entity '0.01' named entity 'diabetes' named entity 'regulatory networks' named entity 'Pneumonia' named entity 'small intestine' named entity 'ACE2' named entity 'cell receptor' named entity 'infection' named entity 'gene' named entity 'pulmonary arterial hypertension' named entity 'chronic diseases' named entity 'organ' named entity 'ACE2' named entity 'retrospective cohort studies' named entity 'Gene Expression Omnibus' named entity 'COVID' named entity 'Student's t test' named entity 'physiological' named entity 'ACE2' named entity 'gene expression' named entity 'failing hearts' named entity 'ACE2' named entity 'Cancer Genome Atlas' named entity 'tumours'

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