About: The behaviour in vitro of attenuated recombinant influenza viruses

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About: The behaviour in vitro of attenuated recombinant influenza viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The behaviour in vitro of attenuated recombinant influenza viruses
Creator	Mostow, S Tyrrezl, D
Source	PMC
abstract	Influenza strains produced by recombination and tested as possible live vaccine candidates were studied in organ cultures of trachea. Two strains which proved to be too virulent in human volunteers regularly caused damage to the ciliated epithelium and viruses grew to high titre. Two strains which proved to be attenuated for volunteers did not cause appreciable damage, although they replicated to low titre in the epithelium. Similar results were obtained with influenza A virus attenuated by passage in the presence of horse sera. The method may be of value for detecting virulent live influenza vaccine candidates without risking severe illness in volunteers.
has issue date	1973-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01556156
bibo:pmid	4799157
has license	no-cc
sha1sum (hex)	4b95c516405830415f1d82d50f89a50510f0bc93
schema:url	https://doi.org/10.1007/bf01556156
resource representing a document's title	The behaviour in vitro of attenuated recombinant influenza viruses
has PubMed Central identifier	PMC7086870
has PubMed identifier	4799157
schema:publication	Arch Gesamte Virusforsch
resource representing a document's body	covid:4b95c516405830415f1d82d50f89a50510f0bc93#body_text
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