About: Liposome-Coupled Peptides Induce Long-Lived Memory CD8(+) T Cells Without CD4(+) T Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Liposome-Coupled Peptides Induce Long-Lived Memory CD8(+) T Cells Without CD4(+) T Cells
Creator	Kakiuchi, T Tanaka, Y Taneichi, M Uchida, T
Source	Medline; PMC
abstract	CD8(+) T cells provide broad immunity to viruses, because they are able to recognize all types of viral proteins. Therefore, the development of vaccines capable of inducing long-lived memory CD8(+) T cells is desired to prevent diseases, especially those for which no vaccines currently exist. However, in designing CD8(+) T cell vaccines, the role of CD4(+) T cells in the induction and maintenance of memory CD8(+) T cells remains uncertain. In the present study, the necessity or not of CD4(+) T cells in the induction and maintenance of memory CD8(+) T cells was investigated in mice immunized with liposome-coupled CTL epitope peptides. When OVA-derived CTL epitope peptides were chemically coupled to the surfaces of liposomes and inoculated into mice, both primary and secondary CTL responses were successfully induced. The results were further confirmed in CD4(+) T cell-eliminated mice, suggesting that CD4(+) T cells were not required for the generation of memory CD8(+) T cells in the case of immunization with liposome-coupled peptides. Thus, surface-linked liposomal antigens, capable of inducing long-lived memory CD8(+) T cells without the contribution of CD4(+) T cells, might be applicable for the development of vaccines to prevent viral infection, especially for those viruses that evade humoral immunity by varying their surface proteins, such as influenza viruses, HIV, HCV, SARS coronaviruses, and Ebola viruses.
has issue date	2010-11-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0015091
bibo:pmid	21264321
has license	cc-by
sha1sum (hex)	4b2a69ec1289a04f3a94db719f855631f93f2d54
schema:url	https://doi.org/10.1371/journal.pone.0015091
resource representing a document's title	Liposome-Coupled Peptides Induce Long-Lived Memory CD8(+) T Cells Without CD4(+) T Cells
has PubMed Central identifier	PMC3020143
has PubMed identifier	21264321
schema:publication	PLoS One
resource representing a document's body	covid:4b2a69ec1289a04f3a94db719f855631f93f2d54#body_text
is schema:about of	named entity 'TO PREVENT' named entity 'VIRAL INFECTION' named entity 'T CELL' named entity 'NECESSITY' named entity 'VARYING' named entity 'SURFACE' named entity 'HCV' named entity 'INDUCED' named entity 'T CELLS' named entity 'HUMORAL IMMUNITY' named entity 'VIRUSES' named entity 'CASE' named entity 'EPITOPE' named entity 'EXIST' named entity 'VIRAL PROTEINS' named entity 'PRESENT' named entity 'RESPONSES' named entity 'LIPOSOMES' named entity 'IMMUNIZED' named entity 'CD4' named entity 'T CELLS' named entity 'vaccines' named entity 'CD8' named entity 'CD8' named entity 'SURFACES' named entity 'INDUCTION' named entity 'INFLUENZA VIRUSES' named entity 'SECONDARY' named entity 'OVA' named entity 'MIGHT BE' named entity 'DERIVED' named entity 'BROAD' named entity 'SURFACE PROTEINS' named entity 'APPLICABLE' named entity 'DISEASES' named entity 'STUDY' named entity 'PRIMARY' named entity 'TYPES' named entity 'CONFIRMED' named entity 'PEPTIDES' named entity 'MEMORY' named entity 'INDUCING' named entity 'LONG' named entity 'ROLE' named entity 'MICE' named entity 'CTL' named entity 'CD4' named entity 'LIPOSOME' named entity 'LONG' named entity 'COUPLED' named entity 'INDUCE' named entity 'CORONAVIRUSES' named entity 'CD8' named entity 'CURRENTLY' named entity 'EBOLA' named entity 'CAPABLE' named entity 'LIPOSOME' named entity 'ANTIGENS' named entity 'CONTRIBUTION' named entity 'UNCERTAIN' named entity 'PEPTIDES' named entity 'MEMORY' named entity 'INVESTIGATED' named entity 'RECOGNIZE' named entity 'DEVELOPMENT' named entity 'ELIMINATED' named entity 'MAINTENANCE' named entity 'NOT REQUIRED' named entity 'COUPLED' named entity 'THEIR' named entity 'LIPOSOMAL' named entity 'PROVIDE' named entity 'SARS' named entity 'IMMUNITY' named entity 'GENERATION' named entity 'HIV' named entity 'VACCINES' named entity 'CHEMICALLY'

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