About: The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation

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About: The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation
Creator	Garoff, Henrik Huylebroeck, Danny Liljestr6m, Peter Robinson, Andrew Tillman, Ullrich
source	Medline; PMC
abstract	So far it has been demonstrated that the signal sequence of proteins which are made at the ER functions both at the level of protein targeting to the ER and in initiation of chain translocation across the ER membrane. However, its possible role in completing the process of chain transfer (see Singer, S. J., P. A. Maher, and M. P. Yaffe. Proc. Natl. Acad. Sci. USA. 1987. 84:1015-1019) has remained elusive. In this work we show that the p62 protein of Semliki Forest virus contains an uncleaved signal sequence at its NH2-terminus and that this becomes glycosylated early during synthesis and translocation of the p62 polypeptide. As the glycosylation of the signal sequence most likely occurs after its release from the ER membrane our results suggest that this region has no role in completing the transfer process.
has issue date	1990-09-01(xsd:dateTime)
bibo:pmid	2391367
has license	cc-by-nc-sa
sha1sum (hex)	4b1b2e95b29b2fb4926c6c0191689f86537985bb
resource representing a document's title	The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation
has PubMed Central identifier	PMC2116283
has PubMed identifier	2391367
schema:publication	J Cell Biol
resource representing a document's body	covid:4b1b2e95b29b2fb4926c6c0191689f86537985bb#body_text
is schema:about of	named entity 'SIGNAL SEQUENCE' named entity 'CHAIN' named entity 'GLYCOSYLATED' named entity 'LEVEL' named entity 'ITS' named entity 'SEMLIKI FOREST VIRUS' named entity '1987' named entity 'PROTEIN TARGETING' named entity 'POSSIBLE' named entity 'SYNTHESIS' named entity 'CHAIN TRANSFER' named entity 'OUR' named entity 'CHAIN' named entity 'REGION' named entity 'SIGNAL SEQUENCE' named entity 'TERMINUS' named entity 'EARLY' named entity 'PROTEIN ' named entity '1987' named entity 'chain' named entity 'level' named entity 'region' named entity 'completing' named entity 'INVOLVED' named entity 'P62' named entity '1019' named entity 'MOST LIKELY' named entity 'BUT' named entity 'SEMLIKI FOREST VIRUS' covid:arg/4b1b2e95b29b2fb4926c6c0191689f86537985bb named entity 'TRANSLOCATION' named entity 'SUGGEST' named entity 'ACAD' named entity 'SCI' named entity 'PROTEIN ' named entity 'TRANSLOCATION' named entity 'P62' named entity 'POLYPEPTIDE' named entity 'FUNCTIONS' named entity 'USA' named entity 'PROC' named entity 'CONTAINS' named entity 'SINGER' named entity 'FAR' named entity 'NH2' named entity 'PROCESS' named entity 'RESULTS' named entity 'ACROSS' named entity 'ER MEMBRANE' named entity 'GLYCOSYLATION' named entity 'WORK' named entity 'INITIATION' named entity 'PROTEINS' named entity 'INITIATION' named entity 'RELEASE' named entity 'DEMONSTRATED' named entity 'TRANSFER' named entity 'ROLE' named entity 'functions' named entity 'Acad' named entity 'protein targeting' named entity 'signal sequence' named entity 'chain transfer' named entity 'polypeptide' named entity 'S. J.' named entity 'signal sequence' named entity 'p62' named entity 'Semliki Forest Virus' named entity 'Signal Sequence' named entity 'Triton X-100' named entity 'coding region' named entity 'sticky ends' named entity 'alpha helix' named entity 'beta-lactamase' named entity 'p62' named entity 'glycosylation' named entity 'reporter molecules' named entity 'bacteria' named entity 'sugar'

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