About: A modular framework for the development of targeted Covid-19 blood transcript profiling panels

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About: A modular framework for the development of targeted Covid-19 blood transcript profiling panels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A modular framework for the development of targeted Covid-19 blood transcript profiling panels
Creator	Bassetti, Matteo Chaussabel, Damien Altman, Matthew Alfaki, Mohamed Baldwin, Nicole Ballestrero, Alberto Bedognetti, Davide Branco, Ricardo Brummaier, Tobias Calderone, Zohreh De Maria, Andrea Deola, Sara Garand, Mathieu Kabeer, Basirudeen Rinchai, Darawan Tang, Benjamin Toufiq, Mohammed Zoppoli, Gabriele
Source	BioRxiv
abstract	Covid-19 morbidity and mortality are associated with a dysregulated immune response. Tools are needed to enhance existing immune profiling capabilities in affected patients. Here we aimed to develop an approach to support the design of focused blood transcriptome panels for profiling the immune response to SARS-CoV-2 infection. We designed a pool of candidates based on a pre-existing and well-characterized repertoire of blood transcriptional modules. Available Covid-19 blood transcriptome data was also used to guide this process. Further selection steps relied on expert curation. Additionally, we developed several custom web applications to support the evaluation of candidates. As a proof of principle, we designed three targeted blood transcript panels, each with a different translational connotation: therapeutic development relevance, SARS biology relevance and immunological relevance. Altogether the work presented here may contribute to the future expansion of immune profiling capabilities via targeted profiling of blood transcript abundance in Covid-19 patients.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.107243
has license	biorxiv
sha1sum (hex)	4b0be0ae3ab7c6a3f35363019f47a0c414370740
schema:url	https://doi.org/10.1101/2020.05.20.107243
resource representing a document's title	A modular framework for the development of targeted Covid-19 blood transcript profiling panels
schema:publication	bioRxiv
resource representing a document's body	covid:4b0be0ae3ab7c6a3f35363019f47a0c414370740#body_text
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