About: Elevated d-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

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About: Elevated d-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated d-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
Creator	Lakkireddy, Dhanunjaya Turagam, Mohit Patel, Foram Patel, Siddharth Shah, Kuldeep Shah, Siddharth Velagapudi, Poonam Osman, Mohammed Garg, Jalaj
Source	Medline; PMC
abstract	The 2019 novel coronavirus, declared a pandemic, has infected 2.6 million people as of April 27, 2020, and has resulted in the death of 181,938 people. d-dimer is an important prognostic tool, is often elevated in patients with severe coronavirus disease-19 (COVID-19) infection and in those who suffered death. In this systematic review, we aimed to investigate the prognostic role of d-dimer in COVID-19-infected patients. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting admission d-dimer levels in COVID-19 patients and its effect on mortality. Eighteen studies (16 retrospective and 2 prospective) with a total of 3682 patients met the inclusion criteria. The pooled weighted mean difference (WMD) demonstrated significantly elevated d-dimer levels in patients who died versus those who survived (WMD, 6.13 mg/L; 95% confidence interval [CI] 4.16–8.11; P < 0.001). Similarly, the pooled mean d-dimer levels were significantly elevated in patients with severe COVID-19 infection (WMD, 0.54 mg/L; 95% CI 0.28–0.80; P < 0.001). The risk of mortality was fourfold higher in patients with positive d-dimer versus negative d-dimer (risk ratio, 4.11; 95% CI, 2.48–6.84; P < 0.001) and the risk of developing severe disease was twofold higher in patients with positive d-dimer levels versus negative d-dimer (risk ratio, 2.04; 95% CI, 1.34–3.11; P < 0.001). Our meta-analysis demonstrates that patients with COVID-19 infection presenting with elevated d-dimer levels have an increased risk of severe disease and mortality.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1097/crd.0000000000000330
bibo:pmid	32665526
has license	no-cc
sha1sum (hex)	4abbd57641567af5abb8b542bda935a411b1a80f
schema:url	https://doi.org/10.1097/crd.0000000000000330
resource representing a document's title	Elevated d-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
has PubMed Central identifier	PMC7437424
has PubMed identifier	32665526
schema:publication	Cardiol Rev
resource representing a document's body	covid:4abbd57641567af5abb8b542bda935a411b1a80f#body_text
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