About: Diabetes is a risk factor for the progression and prognosis of COVID‐19

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About: Diabetes is a risk factor for the progression and prognosis of COVID‐19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diabetes is a risk factor for the progression and prognosis of COVID‐19
Creator	Wang, Haijun Luo, Shanshan Dong, Yalan Guo, Weina Qin, Renjie Shen, Yin Tian, Chunxia Zhao, \| Zhang, Zili Desheng Hu, \| Haifeng, † Heng, \| Keye Du, \| Mingyue, †
Source	Medline; PMC
abstract	BACKGOUND: To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID‐19). METHODS: A total of 174 consecutive patients confirmed with COVID‐19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. RESULTS: We found that COVID‐19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury‐related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation‐related biomarkers such as IL‐6, C‐reactive protein, serum ferritin and coagulation index, D‐dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID‐19. CONCLUSIONS: Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID‐19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.
has issue date	2020-04-07(xsd:dateTime)
bibo:doi	10.1002/dmrr.3319
bibo:pmid	32233013
has license	cc-by
sha1sum (hex)	4a883a2d60aa1b52f423ee62fe3fbdf19a7b91f0
schema:url	https://doi.org/10.1002/dmrr.3319
resource representing a document's title	Diabetes is a risk factor for the progression and prognosis of COVID‐19
has PubMed Central identifier	PMC7228407
has PubMed identifier	32233013
schema:publication	Diabetes Metab Res Rev
resource representing a document's body	covid:4a883a2d60aa1b52f423ee62fe3fbdf19a7b91f0#body_text
is schema:about of	named entity 'influencing' named entity 'disease' named entity 'metabolic syndrome' named entity 'diabetes' named entity 'virus infections' named entity 'Y.S.' named entity 'binding domain' named entity 'diabetic complications' named entity 'Blood test results' named entity 'diabetes' named entity 'diabetes' named entity 'diabetes' named entity 'macrophage' named entity 'SARS-CoV-2' named entity 'diabetes' named entity 'GGT' named entity 'diabetes' named entity 'morbidity' named entity 'insulin' named entity 'virus' named entity 'diabetes' named entity 'ACE2' named entity 'infection' named entity 'diabetes' named entity 'COVID-19' named entity 'Inflammation' named entity 'Wuhan Union Hospital' named entity 'comorbidities' named entity 'diabetes' named entity 'thrombin' named entity 'diabetes' named entity 'receptor' named entity 'diabetic complications' named entity 'SARS-CoV-2' named entity 'coronavirus disease' named entity 'diabetes' named entity 'diabetes' named entity 'hypercoagulable state' named entity 'multiple organ failure' named entity 'diabetes' named entity 'neutrophils' named entity 'COVID-19' named entity 'ACE2' named entity 'inflammatory factors' named entity 'chemokines' named entity 'SARS-CoV-2' named entity 'inflammation' named entity 'diabetes' named entity 'RNA' named entity 'diabetes' named entity 'diabetes' named entity 'serum ferritin' named entity 'pneumonia' named entity 'diabetes' named entity 'prognosis' named entity 'diabetes' named entity 'SARS-CoV' named entity 'obesity' named entity 'severe pneumonia' named entity 'protein' named entity 'diabetes' named entity 'cardiovascular' named entity 'Ebola' named entity 'pneumonia' named entity 'insulin' named entity 'COVID-19' named entity 'prognosis' named entity 'medical history'

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