About: Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin

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About: Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin
Creator	Covarrubias, Sergio Carnero, Elena Barriocanal, Marina Fortes, Puri Segura, Victor Wu, Min Valadkhan, Saba Western, Case
Source	Medline; PMC
abstract	Many long non-coding RNAs (lncRNAs) are expressed in cells but only a few have been well characterized. In these cases, lncRNAs have been shown to be key regulators of several cellular processes. Therefore, there is a great need to understand the function of more lncRNAs and their regulation in response to stimuli. Interferon (IFN) is a key molecule in the cellular antiviral response. IFN binding to its receptor activates transcription of several IFN-stimulated genes (ISGs) that function as potent antivirals. In addition, several ISGs are positive or negative regulators of the IFN pathway. This is essential to ensure a strong antiviral response and a later return of the cell to homeostasis. As the ISGs described to date are coding genes, we sought to determine whether IFN also regulates the expression of long non-coding ISGs. To this aim, we used RNA sequencing to analyze the transcriptome of control and HuH7 cells treated with IFNα2. The results show that IFN-treatment regulates the expression of several unknown non-coding transcripts. We have validated two lncRNAs upregulated after treatment with different doses of type I IFNα2 in different cells or with type III IFNλ. These lncRNAs were also induced by influenza and vesicular stomatitis virus mutants unable to block the IFN response, but not by several wild-type lytic viruses tested. These lncRNA genes were named lncISG15 and lncBST2 as they are located close to ISGs ISG15 and BST2, respectively. Interestingly, inhibition experiments showed that lncBST2 is a positive regulator of BST2. Therefore lncBST2 has been renamed BISPR, from BST2 IFN-stimulated positive regulator. Our results may have therapeutic implications as lncBST2/BISPR, but also lncISG15 and their coding neighbors, are increased in cells infected with hepatitis C virus and in the liver of infected patients. These results allow us to hypothesize that several lncRNAs could be activated by IFN to control the potency of the antiviral IFN response.
has issue date	2015-01-09(xsd:dateTime)
bibo:doi	10.3389/fimmu.2014.00655
bibo:pmid	25620967
has license	cc-by
sha1sum (hex)	4a698e56af8042a4c35a26127c4da5fc5ff7fa95
schema:url	https://doi.org/10.3389/fimmu.2014.00655
resource representing a document's title	Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin
has PubMed Central identifier	PMC4288319
has PubMed identifier	25620967
schema:publication	Front Immunol
resource representing a document's body	covid:4a698e56af8042a4c35a26127c4da5fc5ff7fa95#body_text
is schema:about of	named entity 'FACTOR' named entity 'WORK' named entity 'INDUCED' named entity 'TETHERIN' named entity 'LONG NON-CODING RNA' named entity 'BST2' named entity 'IFN' named entity 'EXPRESSION' named entity 'ANTIVIRAL' named entity 'HAVE' covid:arg/4a698e56af8042a4c35a26127c4da5fc5ff7fa95 named entity 'Long non-coding RNA' named entity 'expression levels' named entity 'IRF1' named entity 'human genome' named entity 'ISG15' named entity 'ISGs' named entity 'interferon' named entity 'ORF' named entity 'ribosomes' named entity 'IRF3' named entity 'GAPDH' named entity 'statistical significance' named entity 'non-parametric' named entity 'Wakita' named entity 'ISG' named entity 'LncRNA' named entity 'IFNλ' named entity 'IFN' named entity 'data analysis' named entity 'cell lines' named entity 'Immunology' named entity 'nuclear RNAs' named entity 'Spain' named entity 'p-value' named entity 'BST2' named entity 'ISG15' named entity 'ISG15' named entity 'Bioconductor' named entity 'Ad5' named entity 'HIV' named entity 'protein-coding gene' named entity 'dendritic cells' named entity 'expression analysis' named entity 'RNA' named entity 'ISG15' named entity 'sequenced' named entity 'SARS coronavirus' named entity 'response elements' named entity 'IFN' named entity 'lncRNA' named entity 'ruxolitinib' named entity 'ubiquitin-like protein' named entity 'ORFs' named entity 'infection' named entity 'Adenovirus' named entity 'canonical pathway' named entity 'antisense' named entity 'ISG15' named entity 'IFN' named entity 'mRNA' named entity 'Agilent Technologies' named entity 'RNA extraction' named entity 'expression levels' named entity 'VSV' named entity 'BST2' named entity 'HIV' named entity 'HCV' named entity 'vesicular stomatitis' named entity 'DNA viruses' named entity 'homology' named entity 'HCV' named entity 'cytoplasm' named entity 'BST2'

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