About: Intracranial pressure monitors associated with increased venous thromboembolism in severe traumatic brain injury

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About: Intracranial pressure monitors associated with increased venous thromboembolism in severe traumatic brain injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intracranial pressure monitors associated with increased venous thromboembolism in severe traumatic brain injury
Creator	Grigorian, Areg Lekawa, · Nahmias, Jeffry Schubl, Sebastian Allen, Angela Joe, · Barrios, Cristobal Borris Borazjani, · Christian, Ashton
Source	PMC
abstract	BACKGROUND: Utilization of intracranial pressure monitors (ICPMs) has not been consistently shown to improve mortality in patients with severe traumatic brain injury (TBI). A single-center analysis concluded that venous thromboembolism (VTE) chemoprophylaxis (CP) posed no significant bleeding risk in patients following ICPM implementation; however, there is still debate about the optimal use and timing of CP in patients with ICPMs for fear of worsening intracranial hemorrhage. We hypothesized that ICPM use is associated with increased time to VTE CP and thus increased VTE in patients with severe TBI. METHODS: A retrospective analysis of the Trauma Quality Improvement Program (2010–2016) was performed to compare severe TBI patients with and without ICPMs. A multivariable logistic regression analysis was completed. RESULTS: From 35,673 patients with severe TBI, 12,487 (35%) had an ICPM. Those with ICPMs had a higher rate of VTE CP (64.3% vs. 49.4%, p < 0.001) but a longer median time to CP initiation (5 vs. 4 days, p < 0.001) as well as a longer hospital length of stay (LOS) (18 vs. 9 days, p < 0.001) compared to those without ICPMs. After adjusting for covariates, ICPM use was found to be associated with a higher risk of VTE (9.2% vs 4.3%, OR = 1.75, CI = 1.42–2.15, p < 0.001). CONCLUSIONS: Compared to patients without ICPMs, those with ICPMs had a longer delay to initiation of CP leading to an increase in VTE. In addition, there was a nearly two-fold higher associated risk for VTE in patients with ICPMs even when controlling for known VTE risk factors. Improved adherence to initiation of CP in the setting of ICPMs may help decrease the associated risk of VTE with ICPMs.
has issue date	2020-03-10(xsd:dateTime)
bibo:doi	10.1007/s00068-020-01336-x
bibo:pmid	32157341
has license	no-cc
sha1sum (hex)	4a4e5e7ba1b8d150e43bd551a5ff8977d104b6f7
schema:url	https://doi.org/10.1007/s00068-020-01336-x
resource representing a document's title	Intracranial pressure monitors associated with increased venous thromboembolism in severe traumatic brain injury
has PubMed Central identifier	PMC7222950
has PubMed identifier	32157341
schema:publication	Eur J Trauma Emerg Surg
resource representing a document's body	covid:4a4e5e7ba1b8d150e43bd551a5ff8977d104b6f7#body_text
is schema:about of	named entity 'adherence' named entity 'chemoprophylaxis' named entity 'LOS' named entity 'Results' named entity 'risk' named entity 'Surgery' named entity 'FOUND' named entity 'WORSENING' named entity 'KNOWN' named entity 'MORTALITY' named entity 'COMPLETED' named entity 'TO COMPARE' named entity 'LEADING' named entity 'IMPLEMENTATION' named entity 'INCREASE' named entity 'TIME' named entity '2818' named entity 'SEVERE' named entity 'VENOUS THROMBOEMBOLISM' named entity 'SINGLE' named entity 'RETROSPECTIVE ANALYSIS' named entity 'TBI' named entity 'posed' named entity 'VTE' named entity 'addition' named entity 'severe' named entity 'VTE' named entity 'multivariable' named entity 'mortality' named entity 'retrospective' named entity 'risk' named entity 'traumatic brain injury (TBI)' named entity 'patients' named entity 'ICPMs' named entity 'risk factors' named entity 'venous thromboembolism' named entity 'LOS' named entity 'ICPMs' named entity 'VTE' named entity 'higher risk' named entity 'Journal of Trauma' named entity 'TBI' named entity 'risk' named entity 'CT scan' named entity 'ICPMs' named entity 'AKI' named entity 'skewness' named entity 'interaction variable' named entity 'unfractionated heparin' named entity 'ESRD' named entity 'VTE' named entity 'VTE' named entity 'COPD' named entity 'CHF' named entity 'severe head injuries' named entity 'packed red blood cells' named entity 'abdomen' named entity 'pneumonia' named entity 'pneumonia' named entity 'LMWH' named entity 'VTE' named entity 'intermittent pneumatic compression' named entity 'LMWH' named entity 'catheter' named entity 'ISS' named entity 'significant difference' named entity 'chemoprophylaxis' named entity 'missing data' named entity 'CT scan' named entity 'CT scan' named entity 'logistic regression' named entity 'rate of mortality' named entity 'VTE'

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