About: Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report

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About: Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report
Creator	Carugati, Manuela Ormas, Valentina Pozzetti, Ugo Piconi, Stefania Castaldo, Gioacchino Faccioli, Paolo Franzetti, Marco Iemoli, Enrico Longoni, Ernesto Molteni, Chiara Pandolfo, Alessandro
Source	Elsevier; Medline; PMC
abstract	Abstract We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.05.050
bibo:pmid	32422376
has license	els-covid
sha1sum (hex)	4a459b10ba9b140c9c8e89891a97f42f8a9a10da
schema:url	https://doi.org/10.1016/j.ijid.2020.05.050
resource representing a document's title	Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report
has PubMed Central identifier	PMC7228890
has PubMed identifier	32422376
schema:publication	Int J Infect Dis
resource representing a document's body	covid:4a459b10ba9b140c9c8e89891a97f42f8a9a10da#body_text
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