About: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

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About: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Creator	Merad, Miriam Martin, Jerome
Source	Medline; PMC
abstract	The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.1038/s41577-020-0331-4
bibo:pmid	32376901
has license	no-cc
sha1sum (hex)	4a43637aa27b5d38e71b3e7b70d93496d56aad38
schema:url	https://doi.org/10.1038/s41577-020-0331-4
resource representing a document's title	Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
has PubMed Central identifier	PMC7201395
has PubMed identifier	32376901
schema:publication	Nat Rev Immunol
resource representing a document's body	covid:4a43637aa27b5d38e71b3e7b70d93496d56aad38#body_text
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