About: Comparison of atopic and nonatopic children with chronic cough: Bronchoalveolar lavage cell profile

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About: Comparison of atopic and nonatopic children with chronic cough: Bronchoalveolar lavage cell profile Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of atopic and nonatopic children with chronic cough: Bronchoalveolar lavage cell profile
Creator	Bush, Andrew Rodrigues, Joaquim Ferreira, Flavia Filho, Silva Vicente, Luiz Haslam, Patricia
Source	Medline; PMC
abstract	Chronic cough is a common complaint in children and its relationship with asthma is controversial. The aim of the present study was to determine the pattern of airway inflammation in atopic and nonatopic children with chronic cough, and to investigate whether atopy is a predictive factor for eosinophilic inflammation in cough. Bronchoalveolar lavage (BAL; three aliquots of 1 ml/kg saline) was performed in the right middle lobe of 24 (11 atopic and 13 nonatopic) children with persistent cough (8 females, 16 males), mean age 4.7 years (range: 1–11). Atopy was defined as an elevated total serum IgE or a positive RAST test. Both atopic and nonatopic children with persistent cough had an increase in total cells/ml in BAL (atopic: median 39 × 10(4), range: 20–123; nonatopic: median 22 × 10(4), range: 17–132) compared to nonatopic controls (median 11 × 10(4), range 9–30). The increases were mainly in neutrophils (atopic: median 17%, range 2.5–88.5%; nonatopic: median 6%, range 1.0–55.0%) compared to controls (median 1.55%, range 0.5–7.0%; atopics vs. controls, P < 0.005). There were no significant increases in eosinophils, lymphocytes, epithelial cells, or mast cells. Eosinophils were elevated in only 5/11 atopic and none of the nonatopic children. The increased percentage of neutrophils in the BAL fluid of atopic and nonatopic children with persistent cough could be due to an underlying inflammatory process driving the cough, or even conceivably, due to the effect of coughing itself. In this highly selected series, the absence of eosinophilic inflammation in the majority suggests that most would be predicted not to respond to inhaled corticosteroid therapy. This study underscores the need to be cautious about treating coughing children with inhaled corticosteroids, even in the context of a tertiary referral practice. Pediatr Pulmonol. 2007;42:857–863. © 2007 Wiley‐Liss, Inc.
has issue date	2007-08-28(xsd:dateTime)
bibo:doi	10.1002/ppul.20648
bibo:pmid	17726706
has license	no-cc
sha1sum (hex)	4a3db119a260825a3f659f948c4e85491559013e
schema:url	https://doi.org/10.1002/ppul.20648
resource representing a document's title	Comparison of atopic and nonatopic children with chronic cough: Bronchoalveolar lavage cell profile
has PubMed Central identifier	PMC7168020
has PubMed identifier	17726706
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:4a3db119a260825a3f659f948c4e85491559013e#body_text
is schema:about of	named entity 'highly' named entity 'inhaled corticosteroids' named entity 'elevated' named entity 'asthma' named entity 'atopic' named entity 'driving' named entity 'median' named entity 'Profile' named entity 'males' named entity 'pattern' named entity 'context' named entity 'total' named entity 'inflammation' named entity 'eosinophilic' named entity 'Chronic' named entity 'range' named entity 'referral' named entity 'selected' named entity 'positive' named entity 'coughing' named entity 'RAST test' named entity 'coughing' named entity 'Atopic' named entity 'airway' named entity 'eosinophils' named entity 'cough' named entity 'Atopy' named entity 'Eosinophils' named entity 'eosinophilic' named entity 'neutrophils' named entity 'serum' named entity 'cough' named entity 'neutrophils' named entity 'cough' named entity 'eosinophilic' named entity 'cystic fibrosis' named entity 'asthma' named entity 'pertussis' named entity 'respiratory tract infection' named entity 'cough' named entity 'asthma' named entity 'viruses' named entity 'cough' named entity 'atelectasis' named entity 'stridor' named entity 'cotinine' named entity 'eosinophilic' named entity 'cough' named entity '2/24' named entity 'inflammatory process' named entity 'neutrophils' named entity 'cough' named entity 'asthmatic' named entity 'sputum' named entity 'atopy' named entity 'inflammatory process' named entity 'cough' named entity 'cough' named entity 'cough' named entity 'inhaled corticosteroids' named entity 'HEPES' named entity 'ventilator-associated pneumonia' named entity 'inflammation' named entity 'eosinophils' named entity 'asthma' named entity 'relapse' named entity 'outpatient clinic' named entity 'eosinophilic' named entity 'blood count' named entity 'inhaled corticosteroids' named entity 'neutrophilia' named entity 'immunodeficiency' named entity 'cough' named entity 'eosinophilia' named entity 'Atopy' named entity 'statistically significant'

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