About: 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties

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About: 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
Creator	Chen, Qi Liu, Chong Schneller, Stewart Bowlin, Terry
Source	Elsevier; Medline; PMC
abstract	Abstract Synthetically combining the C-4′ side-chain structural features of the antiviral candidates 5′-methylaristeromycin and 5′-homoaristeromycin into a diastereomeric pair of C-4′ side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed.
has issue date	2018-05-15(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2018.03.088
bibo:pmid	29628328
has license	els-covid
sha1sum (hex)	49299c3586fd3c3afa8b43f41ef23066d32f8c0c
schema:url	https://doi.org/10.1016/j.bmcl.2018.03.088
resource representing a document's title	5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
has PubMed Central identifier	PMC7126772
has PubMed identifier	29628328
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:49299c3586fd3c3afa8b43f41ef23066d32f8c0c#body_text
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