About: Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction

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About: Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction
Creator	Yuen, Kwok-Yung Peiris, Malik Davy, Chun-Wai Lau, Yin Law, Hing-Yee Lee, Sik, Allan
topic	covid:48680c8f096d42d9e6d09f711fab46ae08ab89a1#this
Source	Medline; PMC
abstract	Historically, influenza pandemics have arisen from avian influenza viruses. Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates. Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%, which has been attributed to dysregulation of the cytokine system. Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus. The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated. In the present study, we demonstrate that autophagy, a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents, plays a role in cytokine induction. Autophagy is induced to a greater extent by H9N2/G1, in association with cytokine hyperinduction, compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses. Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene, Atg5, we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-α expression in primary human blood macrophages. Our results provide new insights into the pathogenic mechanisms of avian influenza viruses.
has issue date	2010-05-17(xsd:dateTime)
bibo:doi	10.1038/cmi.2010.25
bibo:pmid	20473322
has license	bronze-oa
sha1sum (hex)	48680c8f096d42d9e6d09f711fab46ae08ab89a1
schema:url	https://doi.org/10.1038/cmi.2010.25
resource representing a document's title	Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction
has PubMed Central identifier	PMC4003230
has PubMed identifier	20473322
schema:publication	Cellular & Molecular Immunology
resource representing a document's body	covid:48680c8f096d42d9e6d09f711fab46ae08ab89a1#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/48680c8f096d42d9e6d09f711fab46ae08ab89a1
is schema:about of	named entity 'POTENTIAL' named entity 'pandemic' named entity 'play' named entity 'virus' named entity 'responses' named entity 'greater' named entity 'avian influenza' named entity 'VIRUS INFECTION' named entity 'MECHANISMS' named entity 'EXCESS' named entity 'HOMEOSTATIC PROCESS' named entity 'H5N1 VIRUS' named entity 'PATHOGENIC' named entity 'CELLULAR' named entity 'GREATER' named entity 'SYSTEM' named entity 'EXPRESSION' named entity 'ASSOCIATION' named entity 'INFLUENZA VIRUSES' named entity 'H5N1' named entity 'INDUCED' named entity 'GENOTYPES' named entity 'MORTALITY' named entity '60%' named entity 'VIRUS' named entity 'GENE' named entity 'AUTOPHAGY' named entity 'INDUCTION' named entity 'HUMANS' named entity 'INDUCTION' named entity 'INTERFERON-ALPHA' named entity 'INFLUENZA A' named entity 'EXPRESS' named entity 'INFECTED' named entity 'MACROPHAGES' named entity 'CYTOKINE ' named entity 'EXTENT' named entity 'PRESENT' named entity 'PANDEMICS' named entity 'RESPONSE TO' named entity 'ROLE' named entity 'CXCL10' named entity 'CELLULAR RESPONSE' named entity 'AVIAN INFLUENZA' named entity 'HUMAN BLOOD' named entity 'PROVIDE' named entity 'OUR' named entity 'INSIGHTS' named entity 'UNDERLYING' named entity 'NEW' named entity 'ORIGIN' named entity '3-METHYLADENINE' named entity 'RESULTS' named entity 'DIGESTION' named entity 'SMALL INTERFERING RNA' named entity 'SEASONAL INFLUENZA' named entity 'ATG5' named entity 'HUMAN' named entity 'FULLY' named entity 'PLAY' named entity 'INFLUENZA VIRUS' named entity 'INFLUENZA VIRUS' named entity 'MARKEDLY' named entity 'HAVE' named entity 'ROLE' named entity 'H1N1' named entity 'SILENCE' named entity 'SELF' named entity 'NOVEL' named entity 'AUTOPHAGY' named entity 'INTERFERON' named entity 'PRIMARY' named entity 'INFECTION'

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