About: Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes

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About: Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes
Creator	Ludwig, Stephan Anhlan, Darisuren Brunotte, Linda Boff, Laurita Drexler, Hannes Krischuns, Tim Schreiber, André Schuberth, Christian Wedlich-Söldner, Roland
Source	PMC
abstract	Influenza viruses (IV) exploit a variety of signaling pathways. Previous studies showed that the rapidly accelerated fibrosarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (Raf/MEK/ERK) pathway is functionally linked to nuclear export of viral ribonucleoprotein (vRNP) complexes, suggesting that vRNP export is a signaling-induced event. However, the underlying mechanism remained completely enigmatic. Here we have dissected the unknown molecular steps of signaling-driven vRNP export. We identified kinases RSK1/2 as downstream targets of virus-activated ERK signaling. While RSK2 displays an antiviral role, we demonstrate a virus-supportive function of RSK1, migrating to the nucleus to phosphorylate nucleoprotein (NP), the major constituent of vRNPs. This drives association with viral matrix protein 1 (M1) at the chromatin, important for vRNP export. Inhibition or knockdown of MEK, ERK or RSK1 caused impaired vRNP export and reduced progeny virus titers. This work not only expedites the development of anti-influenza strategies, but in addition demonstrates converse actions of different RSK isoforms.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1073/pnas.2002828117
bibo:pmid	32601201
has license	cc-by-nc-nd
sha1sum (hex)	482e34ce0e50bb8dad46548ebfe5b5d15f2034a6
schema:url	https://doi.org/10.1073/pnas.2002828117
resource representing a document's title	Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes
has PubMed Central identifier	PMC7368312
has PubMed identifier	32601201
schema:publication	Proc Natl Acad Sci U S A
resource representing a document's body	covid:482e34ce0e50bb8dad46548ebfe5b5d15f2034a6#body_text
is schema:about of	named entity 'antiviral' named entity 'strategies' named entity 'nucleoprotein' named entity 'virus' named entity 'Inhibition' named entity 'function' named entity 'studies' named entity 'rapidly' named entity 'export' named entity 'constituent' named entity 'extracellular signal-regulated kinase' named entity 'Here' named entity 'nucleoprotein' named entity 'phosphorylate' named entity 'virus' named entity 'extracellular signal-regulated kinase' named entity 'vRNP' named entity 'vRNP' named entity 'ERK) pathway' named entity 'influenza virus' named entity 'ERK) pathway' named entity 'nuclear retention' named entity 'MEK/ERK' named entity 'RSK' named entity 'influenza virus' named entity 'posttranslational' named entity 'RSK' named entity 'vRNP' named entity 'chromatin' named entity 'virus' named entity 'Crm1' named entity 'influenza' named entity 'NaCl' named entity 'Raf' named entity 'matrix protein' named entity 'influenza' named entity 'nuclear retention' named entity 'RSK' named entity 'phosphorylation' named entity 'virus replication' named entity 'MEK inhibitor' named entity 'RNA' named entity 'signaling pathways' named entity 'LMB' named entity 'exchange factor' named entity 'Raf' named entity 'kinase' named entity 'Raf' named entity 'vRNP' named entity 'protein' named entity 'serine' named entity 'M1 protein' named entity 'replication cycle' named entity 'mice' named entity 'C-terminally' named entity 'incubation' named entity 'IAV' named entity 'nuclear localization' named entity 'clinical development' named entity 'MEK/ERK pathway' named entity 'nuclear export' named entity 'IFNβ' named entity 'chromatin' named entity 'nonphosphorylatable' named entity 'biphasic' named entity 'Strep' named entity 'IAV' named entity 'serine' named entity 'influenza virus' named entity 'infection' named entity 'chromatin' named entity 'infection' named entity 'antiviral'

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