About: Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)

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About: Structural disorder in the proteome and interactome of Alkhurma virus (ALKV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)
Creator	Uversky, Vladimir Redwan, Elrashdy Aljaddawi, Abdullah
Source	Medline; PMC
abstract	Infection by the Alkhurma virus (ALKV) leading to the Alkhurma hemorrhagic fever is a common thread in Saudi Arabia, with no efficient treatment or prevention available as of yet. Although the rational drug design traditionally uses information on known 3D structures of viral proteins, intrinsically disordered proteins (i.e., functional proteins that do not possess unique 3D structures), with their multitude of disorder-dependent functions, are crucial for the biology of viruses. Here, viruses utilize disordered regions in their invasion of the host organisms and in hijacking and repurposing of different host systems. Furthermore, the ability of viruses to efficiently adjust and accommodate to their hostile habitats is also intrinsic disorder-dependent. However, little is currently known on the level of penetrance and functional utilization of intrinsic disorder in the ALKV proteome. To fill this gap, we used here multiple computational tools to evaluate the abundance of intrinsic disorder in the ALKV genome polyprotein. We also analyzed the peculiarities of intrinsic disorder predisposition of the individual viral proteins, as well as human proteins known to be engaged in interaction with the ALKV proteins. Special attention was paid to finding a correlation between protein functionality and structural disorder. To the best of our knowledge, this work represents the first systematic study of the intrinsic disorder status of ALKV proteome and interactome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-018-2968-8) contains supplementary material, which is available to authorized users.
has issue date	2018-11-15(xsd:dateTime)
bibo:doi	10.1007/s00018-018-2968-8
bibo:pmid	30443749
has license	no-cc
sha1sum (hex)	47700ff05767c08b898d0ed37918d82737450136
schema:url	https://doi.org/10.1007/s00018-018-2968-8
resource representing a document's title	Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)
has PubMed Central identifier	PMC7079808
has PubMed identifier	30443749
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:47700ff05767c08b898d0ed37918d82737450136#body_text
is schema:about of	named entity 'intrinsic' named entity 'computational' named entity 'viruses' named entity 'proteome' named entity 'disordered' named entity 'ability' named entity 'attention' named entity 'ENGAGED' named entity 'ANALYZED' named entity 'COMPUTATIONAL' named entity 'PROTEIN ' named entity 'INTRINSICALLY DISORDERED PROTEINS' named entity 'BIOLOGY' named entity 'HERE' named entity 'TOOLS' named entity 'DEPENDENT' named entity 'PREVENTION' named entity 'HOST' named entity 'DO NOT' named entity 'EFFICIENT' named entity 'REGIONS' named entity 'HUMAN PROTEINS' named entity 'FUNCTIONS' named entity 'DIFFERENT' named entity 'TREATMENT' named entity 'ALKHURMA VIRUS' named entity 'GAP' named entity 'BEST' named entity 'ADJUST' named entity 'LEVEL' named entity 'PENETRANCE' named entity 'USED' named entity 'PROTEOME' named entity 'DISORDER' named entity 'STUDY' named entity 'IS A' named entity 'CURRENTLY' named entity 'GENOME POLYPROTEIN' named entity 'UNIQUE' named entity '28I' named entity 'STATUS' named entity 'ATTENTION' named entity 'MULTIPLE' named entity 'LEADING' named entity 'HOSTILE' named entity 'ABUNDANCE' named entity 'VIRAL PROTEINS' named entity 'VIRUSES' named entity 'INTERACTION' named entity 'STRUCTURES' named entity 'THEIR' named entity 'RATIONAL DRUG DESIGN' named entity 'INDIVIDUAL' named entity 'INFECTION' named entity 'HABITATS' named entity 'MULTITUDE' named entity 'PROTEINS' named entity 'THREAD' named entity 'POSSESS' named entity 'INTERACTOME' named entity 'DISORDER' named entity 'INTERACTOME' named entity 'A COMMON' named entity 'UTILIZATION' named entity 'ORGANISMS' named entity 'INVASION' named entity 'STRUCTURAL' named entity 'CORRELATION' named entity 'PAID' named entity 'ALKHURMA VIRUS' named entity 'STRUCTURAL' named entity 'ALKHURMA HEMORRHAGIC FEVER' named entity 'PROTEOME' named entity 'SPECIAL' named entity 'SYSTEMS' named entity 'KNOWN' named entity 'ABILITY' named entity 'KNOWLEDGE' named entity 'SAUDI ARABIA'

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