About: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score

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About: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score
Creator	Zhou, Min Wei, Dong Zhang, Xinxin Guo, Lingxi Li, Qingyun Qu, Jieming Wu, Yurong Li, Wu Ong, David Tsigalou, Christina
Source	Medline; PMC
abstract	OBJECTIVE: The aim of this study was to further clarify clinical characteristics and predict mortality risk among patients with viral pneumonia. METHODS: A total of 528 patients with viral pneumonia at RuiJin hospital in Shanghai from May 2015 to May 2019 were recruited. Multiplex real-time RT-PCR was used to detect respiratory viruses. Demographic information, comorbidities, routine laboratory examinations, immunological indexes, etiological detections, radiological images and treatment were collected on admission. RESULTS: 76 (14.4%) patients died within 90 days in hospital. A predictive MuLBSTA score was calculated on the basis of a multivariate logistic regression model in order to predict mortality with a weighted score that included multilobular infiltrates (OR = 5.20, 95% CI 1.41–12.52, p = 0.010; 5 points), lymphocyte ≤ 0.8(∗)10(9)/L (OR = 4.53, 95% CI 2.55–8.05, p < 0.001; 4 points), bacterial coinfection (OR = 3.71, 95% CI 2.11–6.51, p < 0.001; 4 points), acute-smoker (OR = 3.19, 95% CI 1.34–6.26, p = 0.001; 3 points), quit-smoker (OR = 2.18, 95% CI 0.99–4.82, p = 0.054; 2 points), hypertension (OR = 2.39, 95% CI 1.55–4.26, p = 0.003; 2 points) and age ≥60 years (OR = 2.14, 95% CI 1.04–4.39, p = 0.038; 2 points). 12 points was used as a cut-off value for mortality risk stratification. This model showed sensitivity of 0.776, specificity of 0.778 and a better predictive ability than CURB-65 (AUROC = 0.773 vs. 0.717, p < 0.001). CONCLUSION: Here, we designed an easy-to-use clinically predictive tool for assessing 90-day mortality risk of viral pneumonia. It can accurately stratify hospitalized patients with viral pneumonia into relevant risk categories and could provide guidance to make further clinical decisions.
has issue date	2019-12-03(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02752
bibo:pmid	31849894
has license	cc-by
sha1sum (hex)	475d4a59b08bc0524da46806dae55989e57dac4e
schema:url	https://doi.org/10.3389/fmicb.2019.02752
resource representing a document's title	Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score
has PubMed Central identifier	PMC6901688
has PubMed identifier	31849894
schema:publication	Front Microbiol
resource representing a document's body	covid:475d4a59b08bc0524da46806dae55989e57dac4e#body_text
is schema:about of	named entity 'STUDY' named entity 'MORTALITY RISK' named entity 'VIRAL PNEUMONIA' named entity 'AIM' named entity 'OBJECTIVE' named entity 'PREDICT' named entity 'CLINICAL FEATURES' named entity 'PREDICTING' named entity 'PATIENTS' named entity 'VIRAL PNEUMONIA' named entity 'MORTALITY RISK' named entity 'CITATION' named entity 'PATIENTS' named entity 'CLARIFY' named entity 'SCORE' named entity 'CLINICAL CHARACTERISTICS' covid:arg/475d4a59b08bc0524da46806dae55989e57dac4e named entity 'clinical characteristics' named entity 'Mortality Risk' named entity 'infectious diseases' named entity 'IL-6' named entity 'infection' named entity 'blood pressure' named entity 'Pneumonia' named entity 'informed consent' named entity 'virus infection' named entity 'IL-6' named entity 'adenovirus' named entity 'Shanghai' named entity 'chemokines' named entity 'regression coefficient' named entity 'serum levels' named entity 'bacterial infections' named entity 'CAP' named entity 'cross-validation' named entity 'T-lymphocyte' named entity 'respiratory rate' named entity 'viral pneumonia' named entity 'bacterial infection' named entity 'pneumonia' named entity 'IL-10' named entity 'Viral infections' named entity 'high-risk' named entity 'missing data' named entity 'infectious disease' named entity 'T-cell' named entity 'training set' named entity 'RT-PCR' named entity 'cytomegalovirus' named entity 'mortality rate' named entity 'missing data' named entity 'prognosis' named entity 'antigen' named entity 'IL-6' named entity 'infection' named entity 'culture results' named entity 'NRI' named entity 'p-value' named entity 'urea' named entity 'zanamivir' named entity 'IL-10' named entity 'Multiple imputation' named entity 'foscarnet' named entity 'high-risk' named entity 'influenza' named entity 'antiviral treatment' named entity 'CURB-65' named entity 'long-term' named entity 'risk factors' named entity 'CT scanning' named entity 'AdV' named entity 'viruses'

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