About: Association of the bleeding time test with aspects of traumatic brain injury in patients with alcohol use disorder

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About: Association of the bleeding time test with aspects of traumatic brain injury in patients with alcohol use disorder Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of the bleeding time test with aspects of traumatic brain injury in patients with alcohol use disorder
Creator	Enblad, & Hillered, & Marklund, & Rostami, E Tsitsopoulos, P
source	PMC
abstract	BACKGROUND—AIM: Traumatic brain injury (TBI) and alcohol use disorder (AUD) can occur concomitantly and be associated with coagulopathy that influences TBI outcome. The use of bleeding time tests in TBI management is controversial. We hypothesized that in TBI patients with AUD, a prolonged bleeding time is associated with more severe injury and poor outcome. MATERIAL AND METHODS: Moderate and severe TBI patients with evidence of AUD were examined with bleeding time according to IVY bleeding time on admission during neurointensive care. Baseline clinical and radiological characteristics were recorded. A standardized IVY bleeding time test was determined by staff trained in the procedure. Bleeding time test results were divided into normal (≤ 600 s), prolonged (> 600 s), and markedly prolonged (≥ 900 s). Normal platelet count (PLT) was defined as > 150,000/μL. This cohort was compared with another group of TBI patients without evidence of AUD. RESULTS: Fifty-two patients with TBI and AUD were identified, and 121 TBI patients without any history of AUD were used as controls. PLT was low in 44.2% and bleeding time was prolonged in 69.2% of patients. Bleeding time values negatively correlated with PLT (p < 0.05). TBI patients with markedly prolonged values (≥ 900 s) had significantly increased hematoma size, and more frequently required intracranial pressure measurement and mechanical ventilation compared with those with bleeding times < 900 s (p < 0.05). Most patients (88%) with low platelet count had prolonged bleeding time. No difference in 6-month outcome between the bleeding time groups was observed (p > 0.05). Subjects with TBI and no evidence for AUD had lower bleeding time values and higher platelet count compared with those with TBI and history of AUD (p < 0.05). CONCLUSIONS: Although differences in the bleeding time values between TBI cohorts exist and prolonged values may be seen even in patients with normal platelet count, the bleeding test is a marker of primary hemostasis and platelet function with low specificity. However, it may provide an additional assessment in the interpretation of the overall status of TBI patients with AUD. Therefore, the bleeding time test should only be used in combination with the patient’s bleeding history and careful assessment of other hematologic parameters.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1007/s00701-020-04373-y
bibo:pmid	32424564
has license	cc-by
sha1sum (hex)	47582e7b51d9e6a6b35944321fb1763d8c0fa219
schema:url	https://doi.org/10.1007/s00701-020-04373-y
resource representing a document's title	Association of the bleeding time test with aspects of traumatic brain injury in patients with alcohol use disorder
has PubMed Central identifier	PMC7232602
has PubMed identifier	32424564
schema:publication	Acta Neurochir (Wien)
resource representing a document's body	covid:47582e7b51d9e6a6b35944321fb1763d8c0fa219#body_text
is schema:about of	named entity 'hypothesized' named entity 'hematologic' named entity 'alcohol' named entity 'bleeding time' named entity 'bleeding time' named entity 'additional' named entity 'influences' named entity 'aspects' named entity 'disorder' named entity 'correlated' named entity 'bleeding time' named entity 'cohort' named entity 'Normal' named entity 'observed' named entity 'injury' named entity 'platelet' named entity 'test' named entity 'patients' named entity 'TBI' named entity 'count' named entity 'Most' named entity 'determined' named entity 'patients' named entity 'However' named entity 'AUD' named entity 'Subjects' named entity 'TBI' named entity 'exist' named entity 'patients' named entity 'severe' named entity 'test' named entity 'AUD' named entity 'bleeding time' named entity 'TBI' named entity 'platelet count' named entity 'TBI' named entity 'TBI' named entity 'TBI' named entity 'bleeding time' named entity 'AUD' named entity 'neurointensive care' named entity 'TBI' named entity 'bleeding time' named entity 'intracranial pressure' named entity 'bleeding time' named entity 'AUD' named entity 'alcohol use disorder' named entity 'patients' named entity '1.2' named entity 'platelet' named entity 'bleeding time' named entity 'coagulation' named entity 'NICU' named entity 'coagulation abnormalities' named entity 'TBI' named entity 'hemorrhage' named entity 'TBI' named entity 'CPP' named entity 'Microsoft Excel' named entity 'hemostasis' named entity 'reproducibility' named entity 'CT scans' named entity 'Arterial blood gases' named entity 'Decompressive craniectomy' named entity 'CT scan' named entity 'AUD' named entity 'intravenous' named entity 'bleeding time' named entity 'bleeding time' named entity 'mechanically ventilated' named entity 'hemophilia' named entity 'ICD codes' named entity 'hematoma' named entity 'bleeding time' named entity 'Microsoft' named entity 'morphine' named entity 'neurointensive care'

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