About: A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea
Creator	Adamantos, Sophie Montalbano, Christina Morelli, Giada Shmalberg, Justin Buckley, Gareth Gommeren, Kris Smart, Lisa
Source	Medline; PMC
abstract	Acute diarrhea is a common, often self-limiting, cause of presentation for veterinary care, yet there is a paucity of data on frequently-prescribed treatments. The purpose of this randomized, double blinded placebo-controlled clinical trial was to compare two anecdotally-recommended treatments: a probiotic combination and metronidazole. Sixty dogs without concurrent comorbidities were randomized into three treatment groups. The time to resolution of diarrheal signs was evaluated using owner surveys and fecal scoring charts. Dogs presenting with acute diarrhea achieved acceptable fecal consistency after 3.5 ± 2.2 days when receiving probiotic, 4.6 ± 2.4 days with oral metronidazole, and 4.8 ± 2.9 days with placebo; statistically significant differences were not identified between treatment groups (p = 0.17). These findings failed to provide evidence for the common use of metronidazole in this cohort of dogs with acute canine diarrhea, and a larger study population would be required to identify a statistically significant effect of probiotics.
has issue date	2019-06-04(xsd:dateTime)
bibo:doi	10.3389/fvets.2019.00163
bibo:pmid	31275948
has license	cc-by
sha1sum (hex)	4753feb97a6db2b1172caa96791e23e96ac9d287
schema:url	https://doi.org/10.3389/fvets.2019.00163
resource representing a document's title	A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea
has PubMed Central identifier	PMC6593266
has PubMed identifier	31275948
schema:publication	Front Vet Sci
resource representing a document's body	covid:4753feb97a6db2b1172caa96791e23e96ac9d287#body_text
is schema:about of	named entity 'care' named entity 'veterinary' named entity 'acute' named entity 'clinical trial' named entity 'days' named entity 'receiving' named entity 'days' named entity 'Randomized' named entity 'Canine' named entity 'Diarrhea' named entity 'Clinical Trial' covid:arg/4753feb97a6db2b1172caa96791e23e96ac9d287 named entity '28P' named entity 'FREQUENTLY' named entity 'DIARRHEA' named entity '2.4' named entity 'CONCURRENT' named entity 'REQUIRED' named entity 'STATISTICALLY SIGNIFICANT' named entity 'CANINE' named entity 'ORAL METRONIDAZOLE' named entity 'RECOMMENDED' named entity 'USE OF' named entity 'TIME' named entity 'COHORT' named entity 'SIGNS' named entity 'RESOLUTION' named entity 'USING' named entity 'RANDOMIZED' named entity '3.5' named entity 'CHARTS' named entity 'THESE' named entity 'METRONIDAZOLE' named entity 'COMORBIDITIES' named entity 'FAILED' named entity '2.9' named entity 'PROBIOTICS' named entity 'SCORING' named entity 'VETERINARY CARE' named entity 'DOUBLE' named entity 'SIXTY' named entity 'TO IDENTIFY' named entity 'TREATMENTS' named entity 'EFFECT' named entity 'COMMON' named entity 'DOUBLE' named entity 'IS A' named entity 'COMBINATION' named entity 'CONSISTENCY' named entity '0.17' named entity 'DATA' named entity 'SELF' named entity 'PURPOSE' named entity 'OWNER' named entity 'ACCEPTABLE' named entity 'BLINDED' named entity 'DIARRHEA' named entity 'ACUTE' named entity 'BLINDED' named entity 'RANDOMIZED' named entity 'PLACEBO-CONTROLLED' named entity '4.8' named entity 'LARGER' named entity 'DOGS' named entity 'EVALUATED' named entity 'EVIDENCE FOR' named entity 'TO COMPARE' named entity 'SURVEYS' named entity 'CONTROLLED CLINICAL TRIAL' named entity 'TREATMENT' named entity 'NOT IDENTIFIED' named entity 'CAUSE' named entity 'STUDY POPULATION' named entity 'PROBIOTIC' named entity 'CONTROLLED CLINICAL TRIAL'

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