About: Type 3 hypersensitivity in COVID-19 vasculitis

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About: Type 3 hypersensitivity in COVID-19 vasculitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type 3 hypersensitivity in COVID-19 vasculitis
Creator	Gallo, Graziana Manenti, Antonio Roncati, Luca Fabbiani, Luca Ligabue, Giulia Lusenti, Beatrice Maiorana, Antonio Malagoli, Claudia Nasillo, Vincenzo
Source	Elsevier; Medline; PMC
abstract	Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden around the world. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1016/j.clim.2020.108487
bibo:pmid	32479986
has license	no-cc
sha1sum (hex)	474e12e66c6210b9b692365e7bd439a421012fb6
schema:url	https://doi.org/10.1016/j.clim.2020.108487
resource representing a document's title	Type 3 hypersensitivity in COVID-19 vasculitis
has PubMed Central identifier	PMC7256503
has PubMed identifier	32479986
schema:publication	Clin Immunol
resource representing a document's body	covid:474e12e66c6210b9b692365e7bd439a421012fb6#body_text
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